Allergic inflammation disrupts epithelial electrogenic electrolyte transport through cholinergic regulation in the mouse colon

Takeshi Yamamoto*, Yosuke Katsuki, Yuya Kanauchi, Shusaku Hayashi, Makoto Kadowaki

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

抄録

Intestinal transport of electrolytes is regulated by the enteric nervous system. Acetylcholine (ACh) is considered the most important neurotransmitter for electrolyte transport in the colon. However, electrolyte transport regulated by ACh is not fully understood in the colon. We investigated the regulation of electrogenic electrolyte transport by cholinergic agonists in the mouse colon by mea-suring the short-circuit current (Isc) using an Ussing chamber system. Muscarinic stimulation induced transient electrogenic Cl secretion, and nicotinic stimulation induced electrogenic K+ secretion to the apical side in the normal mouse colon, and these effects were reduced in the colon of mice with food allergy (FA). Administration of prednisolone to mice with FA suppressed mild inflammation in the colon and allergic symptoms and thereby ameliorated the disruption of electrogenic electrolyte transport induced not only by cholinergic pathway activation but also by electrical field stimulation and intracellular cAMP signaling pathway activation in the colon. These results suggest that the electrogenic electrolyte transport function in the colon is impaired by FA-induced colonic inflammation and that the suppression of inflammation ameliorates the dys-function of electrogenic electrolyte transport in the colon of mice with FA.

本文言語英語
ページ(範囲)31-40
ページ数10
ジャーナルBiomedical Research (Japan)
44
1
DOI
出版ステータス出版済み - 2023

ASJC Scopus 主題領域

  • 生化学、遺伝学、分子生物学一般

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