Accurate prediction of the stage of histological chorioamnionitis before delivery by amniotic fluid IL-8 level

Satoshi Yoneda, Arihiro Shiozaki, Mika Ito, Noriko Yoneda, Kumiko Inada, Rika Yonezawa, Mika Kigawa, Shigeru Saito*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

42 被引用数 (Scopus)

抄録

Objective: To estimate the stage of histological chorioamnionitis (h-CAM) antenatally using clinical data. Materials and methods: Four hundred and twenty-eight singleton mothers were recruited. Clinical data including the levels of white blood cell count (WBC), C-reactive protein (CRP), amniotic fluid interleukin-8 (AF-IL-8) at Cesarean section, and maternal body temperature (MBT) were collected. Results: Histological chorioamnionitis was present in 45.3% of the cases. Poor neonatal prognosis was highest (59.1%) in cases with h-CAM stage III. AF-IL-8 (odds ratio: 8.5, 95% CI: 5.1-14.8, P < 0.0001) and MBT (odds ratio: 2.3, 95% CI: 1.13-4.1, P = 0.0192) were independent risk factors for h-CAM. The cutoff value of AF-IL-8 for predicting each stage of h-CAM (stage I or higher, stage II or higher, and stage III) were ≥9.9 ng/mL, ≥17.3 ng/mL, and ≥55.9 ng/mL, respectively. Conclusion: The stage of h-CAM was able to be predicted accurately by the level of AF-IL-8 before delivery.

本文言語英語
ページ(範囲)568-576
ページ数9
ジャーナルAmerican Journal of Reproductive Immunology
73
6
DOI
出版ステータス出版済み - 2015/06/01

ASJC Scopus 主題領域

  • 免疫アレルギー学
  • 免疫学
  • 生殖医学
  • 産婦人科学

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