抄録
Th17 cells, a new subset of helper T cells, have been focused on as a producer pro-inflammatory cytokines. It is, however, still unknown how Th17 cells affect pregnancy outcome. We investigated the expression of IL-17-producing cells in human spontaneous abortion.Method of study IL-17 expression was analyzed in decidual tissues among normal pregnancy, missed abortion, and inevitable abortion cases by immunohistochemistry and flow cytometry.Results IL-17+ cells were accumulated in decidua and were detected in decidual CD4+ T cells and few decidual CD8+ T cells in spontaneous abortion cases. The number of decidual IL-17+ cells in inevitable abortion cases involving active genital bleeding was significantly higher than that in normal pregnancy cases (P < 0.05). On the other hand, there were no significant differences in the numbers of decidual IL-17+ cells between missed abortion cases and normal pregnancy subjects. Furthermore, the number of IL-17+ cells was positively correlated with the number of neutrophils in spontaneous abortion cases.Conclusion IL-17+ cells might be involved in the induction of inflammation in the late stage of abortion, but not in the early stage of abortion.
本文言語 | 英語 |
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ページ(範囲) | 4-11 |
ページ数 | 8 |
ジャーナル | American Journal of Reproductive Immunology |
巻 | 64 |
号 | 1 |
DOI | |
出版ステータス | 出版済み - 2010/07 |
ASJC Scopus 主題領域
- 免疫アレルギー学
- 免疫学
- 生殖医学
- 産婦人科学