Accumulation of IL-17-Positive Cells in Decidua of Inevitable Abortion Cases

Akitoshi Nakashima, Mika Ito, Tomoko Shima, Nguyen Duy Bac, Takao Hidaka, Shigeru Saito*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

125 被引用数 (Scopus)

抄録

Th17 cells, a new subset of helper T cells, have been focused on as a producer pro-inflammatory cytokines. It is, however, still unknown how Th17 cells affect pregnancy outcome. We investigated the expression of IL-17-producing cells in human spontaneous abortion.Method of study IL-17 expression was analyzed in decidual tissues among normal pregnancy, missed abortion, and inevitable abortion cases by immunohistochemistry and flow cytometry.Results IL-17+ cells were accumulated in decidua and were detected in decidual CD4+ T cells and few decidual CD8+ T cells in spontaneous abortion cases. The number of decidual IL-17+ cells in inevitable abortion cases involving active genital bleeding was significantly higher than that in normal pregnancy cases (P < 0.05). On the other hand, there were no significant differences in the numbers of decidual IL-17+ cells between missed abortion cases and normal pregnancy subjects. Furthermore, the number of IL-17+ cells was positively correlated with the number of neutrophils in spontaneous abortion cases.Conclusion IL-17+ cells might be involved in the induction of inflammation in the late stage of abortion, but not in the early stage of abortion.

本文言語英語
ページ(範囲)4-11
ページ数8
ジャーナルAmerican Journal of Reproductive Immunology
64
1
DOI
出版ステータス出版済み - 2010/07

ASJC Scopus 主題領域

  • 免疫アレルギー学
  • 免疫学
  • 生殖医学
  • 産婦人科学

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