TY - JOUR
T1 - Abietane Diterpenoids from the Roots of Clerodendrum trichotomum and Their Nitric Oxide Inhibitory Activities
AU - Hu, Hai Jun
AU - Zhou, Yue
AU - Han, Zhu Zhen
AU - Shi, Yan Hong
AU - Zhang, Shu Sheng
AU - Wang, Zheng Tao
AU - Yang, Li
N1 - Publisher Copyright:
© 2018 American Chemical Society and American Society of Pharmacognosy.
PY - 2018/7/27
Y1 - 2018/7/27
N2 - Twelve new abietane diterpenoids (1-12) and 31 known analogues (13-43) were isolated from a medicinal Chinese herb, Clerodendrum trichotomum Thunberg. The absolute configurations of 1-3 were established on the basis of ECD and X-ray crystallography data, whereas that of 4 was elucidated by comparison of experimental and calculated ECD data. Eight diterpenoids, 15,16-dehydroteuvincenone G (1), trichotomin A (4), 2α-hydrocaryopincaolide F (7), villosin C (20), 15-dehydro-17-hydroxycyrtophyllone A (22), demethylcryptojaponol (38), 6β-hydroxydemethylcryptojaponol (39), and trichotomone (43), exerted inhibitory effects against NO production with IC50 values of 5.6-16.1 μM. The structure-activity relationships of the isolated diterpenoids are also estimated.
AB - Twelve new abietane diterpenoids (1-12) and 31 known analogues (13-43) were isolated from a medicinal Chinese herb, Clerodendrum trichotomum Thunberg. The absolute configurations of 1-3 were established on the basis of ECD and X-ray crystallography data, whereas that of 4 was elucidated by comparison of experimental and calculated ECD data. Eight diterpenoids, 15,16-dehydroteuvincenone G (1), trichotomin A (4), 2α-hydrocaryopincaolide F (7), villosin C (20), 15-dehydro-17-hydroxycyrtophyllone A (22), demethylcryptojaponol (38), 6β-hydroxydemethylcryptojaponol (39), and trichotomone (43), exerted inhibitory effects against NO production with IC50 values of 5.6-16.1 μM. The structure-activity relationships of the isolated diterpenoids are also estimated.
UR - http://www.scopus.com/inward/record.url?scp=85050754797&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.7b00814
DO - 10.1021/acs.jnatprod.7b00814
M3 - 学術論文
C2 - 29924604
AN - SCOPUS:85050754797
SN - 0163-3864
VL - 81
SP - 1508
EP - 1516
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 7
ER -