A triglyceride-lowering effect of cattle bile is associated with elevation of cholesterol levels and liver injury in mice

Since cholic acid (CA) has been demonstrated to suppress triglyceride (TG) synthesis, cattle bile (CB) constituted mainly of CA may exert a TG-lowering effect. However, harmful effects of CB such as elevation of cholesterol (Cho) levels and hepatotoxicity are also assumed to be induced. In this study, we demonstrated that diets containing CB at 0.5 and 1.0 % (w/w) reduced TG levels in blood and liver of mice, which was associated with the elevation of Cho levels in blood and liver and liver injury. Our results suggest that practical use of CB as a TG-lowering agent is not recommended.