A review on the current status and definitions of activity indices in inflammatory bowel disease: how to use indices for precise evaluation

Masahiro Kishi, Fumihito Hirai*, Noritaka Takatsu, Takashi Hisabe, Yasumichi Takada, Tsuyoshi Beppu, Ken Takeuchi, Makoto Naganuma, Kazuo Ohtsuka, Kenji Watanabe, Takayuki Matsumoto, Motohiro Esaki, Kazutaka Koganei, Akira Sugita, Keisuke Hata, Kitarou Futami, Yoichi Ajioka, Hiroshi Tanabe, Akinori Iwashita, Hirotaka ShimizuKatsuhiro Arai, Yasuo Suzuki, Tadakazu Hisamatsu

*この論文の責任著者

研究成果: ジャーナルへの寄稿総説査読

41 被引用数 (Scopus)

抄録

Many clinical trials have been conducted for inflammatory bowel disease (IBD), so various clinical indices (CIs) and endoscopic indices (EIs) have also been evaluated. However, recently, with the progress of IBD management, review of established indices from previous studies, and establishment of new indices, the landscape of the use of indices in clinical trials have changed. We investigated the number and frequency of the indices adapted in recent clinical trials for ulcerative colitis (CI and EI) and Crohn’s disease (CI, EI, index related to magnetic resonance imaging, index for evaluating patient-reported outcomes, and health-related quality of life). Based on the results, we selected representative indices and further reviewed their content and characteristics. Moreover, various definitions, including clinical and endoscopic response or remission, have been described by means of representative indices in clinical trials.

本文言語英語
ページ(範囲)246-266
ページ数21
ジャーナルJournal of Gastroenterology
57
4
DOI
出版ステータス出版済み - 2022/04

ASJC Scopus 主題領域

  • 消化器病学

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