TY - JOUR
T1 - A new predictive tool consolidating CURB-65 with procalcitonin and albumin to assess short-term mortality in hospitalized elderly patients with infectious disease
T2 - A retrospective study of a patient cohort
AU - Higashikawa, Toshihiro
AU - Ito, Tomohiko
AU - Mizuno, Takuro
AU - Ishigami, Keiichirou
AU - Kuroki, Kengo
AU - Maekawa, Naoto
AU - Usuda, Daisuke
AU - Nakao, Shinichiro
AU - Hamada, Kazu
AU - Takagi, Susumu
AU - Terada, Nao
AU - Takeshima, Kento
AU - Yamada, Shinya
AU - Sangen, Ryusho
AU - Izumida, Toshihide
AU - Kiyosawa, Jun
AU - Saito, Atsushi
AU - Iguchi, Masaharu
AU - Wato, Hiroyuki
AU - Nakahashi, Takeshi
AU - Kasamaki, Yuji
AU - Fukuda, Akihiro
AU - Kanda, Tsugiyasu
AU - Okuro, Masashi
N1 - Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/11/18
Y1 - 2022/11/18
N2 - Background: Hospitalized elderly patients are often at risk of life-threatening infectious diseases such as pneumonia and urinary tract infection, thus diagnostic tools for bacterial infections are demanded. We developed a new predictive tool consolidating modified CURB-65, procalcitonin (PCT) and albumin (Alb). Method: This is a retrospective study. Modified CURB-65 (mCURB-65) score, PCT, Alb, and various cardiovascular/respiratory/renal functions were measured. Survival analyses were conducted to assess 30-days mortality of elderly patients using mCURB-65 score, PCT and Alb. The consolidated scores were compared with the number of patients died. Results: There were 445 elderly patients included. Kaplan-Meier survival curves showed significant differences between the high and low groups of mCURB-65, PCT and Alb (log-rank test, P < .001). Cox proportional regression showed that the hazard ratios (95% confidence intervals) for high mCURB-65, high Alb, and high PCT were all significant, 1.95 (1.24-3.05), 0.50 (0.32-0.77), and 2.09 (1.32-3.31), respectively. The consolidated scores showed tendency of increase with proportion of the number of patients died. Conclusions: The consolidated score consisted of mCURB-65, PCT and Alb can be a useful tool to predict short-term mortality of the hospitalized elderly patients with infectious disease.
AB - Background: Hospitalized elderly patients are often at risk of life-threatening infectious diseases such as pneumonia and urinary tract infection, thus diagnostic tools for bacterial infections are demanded. We developed a new predictive tool consolidating modified CURB-65, procalcitonin (PCT) and albumin (Alb). Method: This is a retrospective study. Modified CURB-65 (mCURB-65) score, PCT, Alb, and various cardiovascular/respiratory/renal functions were measured. Survival analyses were conducted to assess 30-days mortality of elderly patients using mCURB-65 score, PCT and Alb. The consolidated scores were compared with the number of patients died. Results: There were 445 elderly patients included. Kaplan-Meier survival curves showed significant differences between the high and low groups of mCURB-65, PCT and Alb (log-rank test, P < .001). Cox proportional regression showed that the hazard ratios (95% confidence intervals) for high mCURB-65, high Alb, and high PCT were all significant, 1.95 (1.24-3.05), 0.50 (0.32-0.77), and 2.09 (1.32-3.31), respectively. The consolidated scores showed tendency of increase with proportion of the number of patients died. Conclusions: The consolidated score consisted of mCURB-65, PCT and Alb can be a useful tool to predict short-term mortality of the hospitalized elderly patients with infectious disease.
KW - CURB-65
KW - albumin
KW - hospitalized elderly patients
KW - procalcitonin
UR - http://www.scopus.com/inward/record.url?scp=85142402496&partnerID=8YFLogxK
U2 - 10.1097/MD.0000000000031614
DO - 10.1097/MD.0000000000031614
M3 - 学術論文
C2 - 36401412
AN - SCOPUS:85142402496
SN - 0025-7974
VL - 101
SP - E31614
JO - Medicine
JF - Medicine
IS - 46
ER -