A multicenter prospective randomized study comparing the incidence of periprocedural cerebral embolisms caused by catheter ablation of atrial fibrillation between cryoballoon and radiofrequency ablation (Embo-Abl study): Study design

Koji Miyamoto, Koshiro Kanaoka, Yasutoshi Ohta, Masue Yoh, Hiroki Takahashi, Rena Tonegawa-Kuji, Yuichiro Miyazaki, Keiko Shimamoto, Akinori Wakamiya, Nobuhiko Ueda, Kenzaburo Nakajima, Tsukasa Kamakura, Mitsuru Wada, Kohei Ishibashi, Yuko Inoue, Satoshi Nagase, Takeshi Aiba, Akihisa Narai, Tomohiro Nakase, Masatoshi KogaTetsuya Fukuda, Naoya Kataoka, Masahiko Takagi, Kengo Kusano*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

1 被引用数 (Scopus)

抄録

Background: Although catheter ablation (CA) has become a standard therapeutic approach to atrial fibrillation (AF), it imposes a low but relevant risk of thromboembolic complications of around 0.5%–1%, including ischemic strokes, and has an additional risk of clinically silent cerebral embolisms (SCEs) of 10%–40%. Both cryoballoon (CB) and radiofrequency (RF) ablation are routinely used clinically worldwide, yet there are few prospective data comparing the incidence of cerebral embolism after CA of AF between CB and RF ablation. Methods: The aim of the Embo-Abl study will be to compare the incidence of cerebral embolisms on 3 T diffusion-weighted image magnetic resonance imaging (MRI) after CA of AF between CB and RF ablation in patients with AF in a prospective, multicenter, open-label, controlled, randomized fashion. The primary endpoint of the Embo-Abl study will be the occurrence of MRI-detected SCE 1–3 days after CA. The patients will be registered and randomly assigned to either the CB or RF ablation group in a 1:1 ratio. The study cohort will include 230 patients with AF from a multicenter in Japan. Results: The results of this study are currently under investigation. Conclusion: The Embo-Abl study will be the first to compare the incidence of periprocedural cerebral embolisms caused by CA of AF between CB and RF ablation in a prospective, multicenter, randomized, controlled fashion.

本文言語英語
ページ(範囲)214-222
ページ数9
ジャーナルClinical Cardiology
46
2
DOI
出版ステータス出版済み - 2023/02

ASJC Scopus 主題領域

  • 循環器および心血管医学

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