@article{3b044d73cea04f729a373805f3bbf695,
title = "A convergent total synthesis of antiplasmodial C2 symmetric (+)-ekeberin D4",
abstract = "The first concise total synthesis of C2 symmetric (+)-ekeberin D4 (1) that exhibits antiplasmodial activity has been achieved in total nine steps and 27% yield from the known diol 4. The efficient synthetic method features the regio- and diastereoselective epoxidation of 4 and convergent coupling between half fragments 2 and 3 by taking into account the C2 symmetric property.",
keywords = "Antiplasmodial activity, Ekeberin D, Total synthesis, Triterpenoid",
author = "Takeshi Kodama and Shingo Aoki and Seiho Kikuchi and Tomoki Matsuo and Yoshimitsu Tachi and Keisuke Nishikawa and Yoshiki Morimoto",
note = "Funding Information: We thank Professor Toshio Miyase (University of Shizuoka) for generously supplying a copy of the 1 H NMR spectrum of natural (+)-ekeberin D 4 . This work was financially supported by a Grant-in-Aid for Scientific Research on Basic Research (B) from the Japan Society for the Promotion of Science and the Asahi Glass Foundation . ",
year = "2013",
month = oct,
day = "9",
doi = "10.1016/j.tetlet.2013.08.025",
language = "英語",
volume = "54",
pages = "5647--5649",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd.",
number = "41",
}