TY - JOUR
T1 - A 14-year nationwide epidemiological analysis of delayed endolymphatic hydrops in Japan
AU - Ito, Shinsuke
AU - Takakura, Hiromasa
AU - Akaogi, Katsuichi
AU - Shojaku, Hideo
AU - Takeda, Noriaki
AU - Suzuki, Mamoru
AU - Watanabe, Yukio
AU - Aoki, Mitsuhiro
AU - Doi, Katsumi
AU - Ikezono, Tetsuo
AU - Kakigi, Akinobu
AU - Kitahara, Tadashi
AU - Koizuka, Izumi
AU - Murofushi, Toshihisa
AU - Naganuma, Hideaki
AU - Omori, Koichi
AU - Takahashi, Katsumasa
AU - Takumida, Masaya
AU - Usami, Shin ichi
AU - Yamashita, Hiroshi
N1 - Publisher Copyright:
© 2022 Acta Oto-Laryngologica AB (Ltd).
PY - 2022
Y1 - 2022
N2 - Background: Delayed endolymphatic hydrops (DEH) is an inner ear disease that causes recurrent vertigo in the ipsilateral ear or fluctuating hearing in the contralateral ear due to endolymphatic hydrops secondary to preceding deafness. There are few reports of large, multicentre studies investigating the clinical-epidemiological characteristics of DEH. Objective: This study aimed to clarify the characteristics of DEH in Japan. Methods: Clinical data on 662 patients with DEH were analysed by nationwide, multicentre surveys conducted by the Peripheral Vestibular Disorders Research Group of Japan. Results: The proportion of ipsilateral DEH (IDEH) was slightly higher than that of contralateral DEH (CDEH) at 55.4%. The time delay between onset of precedent deafness and onset of DEH was significantly longer for CDEH than for IDEH. The most common cause of precedent deafness was a disease of unknown cause with onset in early childhood (33.1%). Epidemiological characteristics were not significantly different between CDEH with and without vertigo. Conclusion: DEH appearing to be caused by viral labyrinthitis has a high rate of onset within 40 years of precedent deafness. Clinical and epidemiological characteristics of IDEH, CDEH with vertigo, and CDEH without vertigo were very similar. Significance: The clinical-epidemiological characteristics of DEH in Japan were clarified.
AB - Background: Delayed endolymphatic hydrops (DEH) is an inner ear disease that causes recurrent vertigo in the ipsilateral ear or fluctuating hearing in the contralateral ear due to endolymphatic hydrops secondary to preceding deafness. There are few reports of large, multicentre studies investigating the clinical-epidemiological characteristics of DEH. Objective: This study aimed to clarify the characteristics of DEH in Japan. Methods: Clinical data on 662 patients with DEH were analysed by nationwide, multicentre surveys conducted by the Peripheral Vestibular Disorders Research Group of Japan. Results: The proportion of ipsilateral DEH (IDEH) was slightly higher than that of contralateral DEH (CDEH) at 55.4%. The time delay between onset of precedent deafness and onset of DEH was significantly longer for CDEH than for IDEH. The most common cause of precedent deafness was a disease of unknown cause with onset in early childhood (33.1%). Epidemiological characteristics were not significantly different between CDEH with and without vertigo. Conclusion: DEH appearing to be caused by viral labyrinthitis has a high rate of onset within 40 years of precedent deafness. Clinical and epidemiological characteristics of IDEH, CDEH with vertigo, and CDEH without vertigo were very similar. Significance: The clinical-epidemiological characteristics of DEH in Japan were clarified.
KW - Delayed endolymphatic hydrops
KW - Japanese nationwide survey
KW - contralateral
KW - epidemiological characteristics
KW - ipsilateral
UR - http://www.scopus.com/inward/record.url?scp=85136461982&partnerID=8YFLogxK
U2 - 10.1080/00016489.2022.2108141
DO - 10.1080/00016489.2022.2108141
M3 - 学術論文
C2 - 35984435
AN - SCOPUS:85136461982
SN - 0001-6489
VL - 142
SP - 568
EP - 574
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
IS - 7-8
ER -