@inproceedings{8d07d6698b574c7fbbed124a89c587b6,
title = "2D-SPR biosensor detects the intracellular signal transduction in PC 12 cells at single cell level",
abstract = "Conventional techniques for intracellular signal transduction in living cells can be limited by the need for exogenous labels, time and labor-intensive protocols, as well as by poor sensitivity levels. In this study, 2D-SPR imager was applied to real-time monitoring of intracellular signal transduction at single cell level upon stimulation with carbachol. The reflection intensity change response was suppressed by atropine, D-tubocurarine and staurosporine, respectively. Our results demonstrated that the mammalian cell-based 2D-SPR sensor might develop a pathway to non-labeled, simple, rapid, highly sensitive and multi-detectable biodetection for various chemicals and greatly facilitate high-throughput drug screening, study of molecular biology and so on.",
keywords = "2D-SPR, Atropine, Carbachol, D-tubocurarine, PC12 cells, Staurosporine",
author = "Mir, {Tanveer Ahamd} and Hiroaki Shinohara",
year = "2012",
doi = "10.1109/ICSensT.2012.6461763",
language = "英語",
isbn = "9781467322485",
series = "Proceedings of the International Conference on Sensing Technology, ICST",
pages = "677--681",
booktitle = "2012 6th International Conference on Sensing Technology, ICST 2012",
note = "2012 6th International Conference on Sensing Technology, ICST 2012 ; Conference date: 18-12-2012 Through 21-12-2012",
}