1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-β-D-glucose, a new hepatoprotective constituent from Combretum quadrangulare

K. Adnyana; Y. Tezuka; S. Awale; A. H. Banskota; K. Q. Tran; S. Kadota

doi:10.1055/s-2001-14318

1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-β-D-glucose, a new hepatoprotective constituent from Combretum quadrangulare

K. Adnyana, Y. Tezuka, S. Awale, A. H. Banskota, K. Q. Tran, S. Kadota^*

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

12 被引用数 (Scopus)

抄録

A new gallic acid derivative, 1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-β-D-glucose (1) has been isolated from an H₂O-fraction of MeOH extract of Combretum quadrangulare seeds. Compound 1 exhibited potent hepatoprotective activity against D-Ga1N/TNF-α-induced cell death in primary cultured mouse hepatocytes with an IC₅₀ of 3.3 μM.

本文言語	英語
ページ（範囲）	370-371
ページ数	2
ジャーナル	Planta Medica
巻	67
号	4
DOI	https://doi.org/10.1055/s-2001-14318
出版ステータス	出版済み - 2001

ASJC Scopus 主題領域

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

文献へのアクセス

10.1055/s-2001-14318

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引用スタイル

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abstract = "A new gallic acid derivative, 1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-β-D-glucose (1) has been isolated from an H2O-fraction of MeOH extract of Combretum quadrangulare seeds. Compound 1 exhibited potent hepatoprotective activity against D-Ga1N/TNF-α-induced cell death in primary cultured mouse hepatocytes with an IC50 of 3.3 μM.",

author = "K. Adnyana and Y. Tezuka and S. Awale and Banskota, {A. H.} and Tran, {K. Q.} and S. Kadota",

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AU - Tezuka, Y.

AU - Awale, S.

AU - Banskota, A. H.

AU - Tran, K. Q.

AU - Kadota, S.

PY - 2001

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AB - A new gallic acid derivative, 1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-β-D-glucose (1) has been isolated from an H2O-fraction of MeOH extract of Combretum quadrangulare seeds. Compound 1 exhibited potent hepatoprotective activity against D-Ga1N/TNF-α-induced cell death in primary cultured mouse hepatocytes with an IC50 of 3.3 μM.

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