TY - JOUR
T1 - 胃腺癌化学療法中に原発巣増大をきたし混合型腺神経内分泌腫瘍と診断した 1 例
AU - Fuchino, Mayo
AU - Nakaya, Atsuko
AU - Ando, Takayuki
AU - Hasumoto, Yuushi
AU - Ozawa, Koji
AU - Ito, Hiroyuki
AU - Yabushita, Kazuhisa
AU - Miwa, Shigeharu
AU - Hayashi, Shinichi
N1 - Publisher Copyright:
© 2024 Japanese Society of Gastroenterology. All rights reserved.
PY - 2024
Y1 - 2024
N2 - Gastric mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) is an extremely rare form of gastric neoplasm, and its prognosis is often poor. This is a case report wherein the primary site increased during chemotherapy against gastric adenocarcinoma and was diagnosed with gastric MiNEN after total gastrectomy. A 71-year-old man was diagnosed with gastric adenocarcinoma complicated with liver and para-aortic lymph node metastasis. Chemotherapy with S-1, oxaliplatin, and trastuzumab was initiated. Although the size of metastatic lesions was reduced after six courses of treatment, a part of the primary site of gastric tumor rapidly. Pathological rebiopsy of the primary site suggested a neuroendocrine carcinoma, and he was finally diagnosed with gastric MiNEN after total gastrectomy. Thus, second-line chemotherapy was then initiated showing good response. We herein report a case of MiNEN with a rare diagnostic process.
AB - Gastric mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) is an extremely rare form of gastric neoplasm, and its prognosis is often poor. This is a case report wherein the primary site increased during chemotherapy against gastric adenocarcinoma and was diagnosed with gastric MiNEN after total gastrectomy. A 71-year-old man was diagnosed with gastric adenocarcinoma complicated with liver and para-aortic lymph node metastasis. Chemotherapy with S-1, oxaliplatin, and trastuzumab was initiated. Although the size of metastatic lesions was reduced after six courses of treatment, a part of the primary site of gastric tumor rapidly. Pathological rebiopsy of the primary site suggested a neuroendocrine carcinoma, and he was finally diagnosed with gastric MiNEN after total gastrectomy. Thus, second-line chemotherapy was then initiated showing good response. We herein report a case of MiNEN with a rare diagnostic process.
UR - http://www.scopus.com/inward/record.url?scp=85182544585&partnerID=8YFLogxK
U2 - 10.11405/nisshoshi.121.55
DO - 10.11405/nisshoshi.121.55
M3 - 学術論文
C2 - 38220181
AN - SCOPUS:85182544585
SN - 0446-6586
VL - 121
SP - 55
EP - 62
JO - Journal of Japanese Society of Gastroenterology
JF - Journal of Japanese Society of Gastroenterology
IS - 1
ER -