Role of CD206 surface antigen on M2 macrophages in the development of insulin resistance in the diet-induced obese mice model

Furthermore, I will evaluate the underlying mechanism of how CD206 deficient macrophages are challenging to develop LAMs, how CD206+ M2-like macrophages uptake free fatty acids (FFA) to become LAMs, and how miRNAs derived from LAMs-exosome suppress metabolic favorable genes to develop insulin resistance.