Restoration of NAD+ via inhibition of CD38 improves aging-induced decline in muscle stem cells functions and muscle regeneration

Aging-related decline in NAD+ is reported to impair regenerative process. CD38 is an ectoenzyme to degrade NAD+ and is reportedly increased in inflammatory macrophages during aging. In this study, I will clarify the role of CD38 in the regulation of muscle stem cell functions in aged mice. Thus, my study may provide a clue that inhibition of CD38 restore functions of aged muscle stem cell functions. Reduction in CD38 boosts NAD+ and may rescue aging- and obesity-induced delay in muscle regeneration. Metabolic reprogramming in macrophages could open new field to boost the regenerative process.