Takeshi Yokoyama

2004

Novel mechanisms of pH sensitivity in tuna hemoglobin. A structural explanation of the root effect

Yokoyama, T., Chong, K. T., Miyazaki, G., Morimoto, H., Shih, D. T. B., Unzai, S., Tame, J. R. H. & Park, S. Y., 2004/07/02, In: Journal of Biological Chemistry. 279, 27, p. 28632-28640 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

62 被引用数 (Scopus)

2006

1.25 Å Resolution Crystal Structures of Human Haemoglobin in the Oxy, Deoxy and Carbonmonoxy Forms

Park, S. Y., Yokoyama, T., Shibayama, N., Shiro, Y. & Tame, J. R. H., 2006/07/14, In: Journal of Molecular Biology. 360, 3, p. 690-701 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

270 被引用数 (Scopus)

Crystal structure of oxidized cytochrome c_6A from Arabidopsis thaliana

Chida, H., Yokoyama, T., Kawai, F., Nakazawa, A., Akazaki, H., Takayama, Y., Hirano, T., Suruga, K., Satoh, T., Yamada, S., Kawachi, R., Unzai, S., Nishio, T., Park, S. Y. & Oku, T., 2006/06/26, In: FEBS Letters. 580, 15, p. 3763-3768 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

14 被引用数 (Scopus)

Rounding up: Engineering 12-Membered Rings from the Cyclic 11-Mer TRAP

Heddle, J. G., Yokoyama, T., Yamashita, I., Park, S. Y. & Tame, J. R. H., 2006/05, In: Structure. 14, 5, p. 925-933 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

38 被引用数 (Scopus)

R-state haemoglobin with low oxygen affinity: Crystal structures of deoxy human and carbonmonoxy horse haemoglobin bound to the effector molecule L35

Yokoyama, T., Neya, S., Tsuneshige, A., Yonetani, T., Park, S. Y. & Tame, J. R. H., 2006/02/24, In: Journal of Molecular Biology. 356, 3, p. 790-801 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

42 被引用数 (Scopus)

2007

The structure of the Haemophilus influenzae HMW1 pro-piece reveals a structural domain essential for bacterial two-partner secretion

Yeo, H. J., Yokoyama, T., Walkiewicz, K., Kim, Y., Grass, S. & St. Geme, J. W., 2007/10/19, In: Journal of Biological Chemistry. 282, 42, p. 31076-31084 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

50 被引用数 (Scopus)

2008

Structure of a σ²⁸-Regulated Nonflagellar Virulence Protein from Campylobacter jejuni

Yokoyama, T., Paek, S., Ewing, C. P., Guerry, P. & Yeo, H. J., 2008/12/12, In: Journal of Molecular Biology. 384, 2, p. 364-376 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

9 被引用数 (Scopus)

2009

Campylobacter jejuni fatty acid synthase II: Structural and functional analysis of β-hydroxyacyl-ACP dehydratase (FabZ)

Kirkpatrick, A. S., Yokoyama, T., Choi, K. J. & Yeo, H. J., 2009/03/06, In: Biochemical and Biophysical Research Communications. 380, 2, p. 407-412 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

18 被引用数 (Scopus)

Structure and function of a Campylobacter jejuni thioesterase Cj0915, a hexameric hot dog fold enzyme

Yokoyama, T., Choi, K. J., Bosch, A. M. & Yeo, H. J., 2009/07, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1794, 7, p. 1073-1081 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

15 被引用数 (Scopus)

2010

Neutron structure analysis using the IBARAKI biological crystal diffractometer (iBIX) at J-PARC

Tanaka, I., Kusaka, K., Hosoya, T., Niimura, N., Ohhara, T., Kurihara, K., Yamada, T., Ohnishi, Y., Tomoyori, K. & Yokoyama, T., 2010/11, In: Acta Crystallographica Section D: Biological Crystallography. 66, 11, p. 1194-1197 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

53 被引用数 (Scopus)

2012

Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin

Yokoyama, T., Mizuguchi, M., Nabeshima, Y., Kusaka, K., Yamada, T., Hosoya, T., Ohhara, T., Kurihara, K., Tomoyori, K., Tanaka, I. & Niimura, N., 2012/02, In: Journal of Structural Biology. 177, 2, p. 283-290 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

51 被引用数 (Scopus)

Quaternary structure, aggregation and cytotoxicity of transthyretin

Mizuguchi, M., Yokoyama, T., Nabeshima, Y., Kawano, K., Tanaka, I. & Niimura, N., 2012/06, In: Amyloid. 19, SUPPL. 1, p. 5-7 3 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

2013

Hydrogen-bond network and pH sensitivity in human transthyretin

Yokoyama, T., Mizuguchi, M., Nabeshima, Y., Kusaka, K., Yamada, T., Hosoya, T., Ohhara, T., Kurihara, K., Tanaka, I. & Niimura, N., 2013/11, In: Journal of Synchrotron Radiation. 20, 6, p. 834-837 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

7 被引用数 (Scopus)

2014

Crystallization and preliminary neutron diffraction experiment of human farnesyl pyrophosphate synthase complexed with risedronate

Yokoyama, T., Ostermann, A., Mizuguchi, M., Niimura, N., Schrader, T. E. & Tanaka, I., 2014/04, In: Acta Crystallographica Section:F Structural Biology Communications. 70, 4, p. 470-472 3 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

8 被引用数 (Scopus)

Crystal structures of human transthyretin complexed with glabridin

Yokoyama, T., Kosaka, Y. & Mizuguchi, M., 2014/02/13, In: Journal of Medicinal Chemistry. 57, 3, p. 1090-1096 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

33 被引用数 (Scopus)

Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin

Yokoyama, T., Kosaka, Y. & Mizuguchi, M., 2014/11/13, In: Journal of Medicinal Chemistry. 57, 21, p. 8928-8935 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

43 被引用数 (Scopus)

2015

Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor

Yokoyama, T., Ueda, M., Ando, Y. & Mizuguchi, M., 2015/08/27, In: Scientific Reports. 5, 13570.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

26 被引用数 (Scopus)

Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase

Yokoyama, T., Mizuguchi, M., Ostermann, A., Kusaka, K., Niimura, N., Schrader, T. E. & Tanaka, I., 2015/09/24, In: Journal of Medicinal Chemistry. 58, 18, p. 7549-7556 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

26 被引用数 (Scopus)

Structural Insight into the Interactions between Death-Associated Protein Kinase 1 and Natural Flavonoids

Yokoyama, T., Kosaka, Y. & Mizuguchi, M., 2015/09/24, In: Journal of Medicinal Chemistry. 58, 18, p. 7400-7408 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

69 被引用数 (Scopus)

Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione

Yokoyama, T., Takaki, S., Chosa, K., Sato, T., Suico, M. A., Teranishi, Y., Shuto, T., Mizuguchi, M. & Kai, H., 2015/12, In: Journal of Pharmacological Sciences. 129, 4, p. 240-243 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

5 被引用数 (Scopus)

2017

Large-scale crystallization and neutron crystallographic analysis of HSP70 in complex with ADP

Yokoyama, T., Ostermann, A., Schrader, T. E. & Mizuguchi, M., 2017/10, In: Acta Crystallographica Section:F Structural Biology Communications. 73, 10, p. 555-559 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

Stability and crystal structures of His88 mutant human transthyretins

Yokoyama, T., Hanawa, Y., Obita, T. & Mizuguchi, M., 2017/07/01, In: FEBS Letters. 591, 13, p. 1862-1871 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

15 被引用数 (Scopus)

2018

Characterization of susceptibility variants of poliovirus grown in the presence of favipiravir

Daikoku, T., Mizuguchi, M., Obita, T., Yokoyama, T., Yoshida, Y., Takemoto, M. & Shiraki, K., 2018/10, In: Journal of Microbiology, Immunology and Infection. 51, 5, p. 581-586 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

Inhibition of the amyloidogenesis of transthyretin by natural products and synthetic compounds

Yokoyama, T. & Mizuguchi, M., 2018, In: Biological and Pharmaceutical Bulletin. 41, 7, p. 979-984 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

17 被引用数 (Scopus)

2019

Crown Ethers as Transthyretin Amyloidogenesis Inhibitors

Yokoyama, T. & Mizuguchi, M., 2019/02/28, In: Journal of Medicinal Chemistry. 62, 4, p. 2076-2082 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

25 被引用数 (Scopus)

Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening

Yokoyama, T., Kitakami, R. & Mizuguchi, M., 2019/04/01, In: European Journal of Medicinal Chemistry. 167, p. 153-160 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

16 被引用数 (Scopus)

Structural and thermodynamic characterization of the binding of isoliquiritigenin to the first bromodomain of BRD4

Yokoyama, T., Matsumoto, K., Ostermann, A., Schrader, T. E., Nabeshima, Y. & Mizuguchi, M., 2019/05, In: FEBS Journal. 286, 9, p. 1656-1667 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

7 被引用数 (Scopus)

The effect of amino acid substitution at position 88 on the structure and stability of transthyretin

Yokoyama, T., Hanawa, Y., Obita, T. & Mizuguchi, M., 2019/03/29, In: Amyloid. 26, sup1, p. 43-44 2 p.

研究成果: ジャーナルへの寄稿 › Letter › 査読

Transthyretin Amyloid Fibril Disrupting Activities of Extracts and Fractions from Juglans mandshurica Maxim. Var. Cordiformis (Makino) Kitam.

Chaudhary, N., Sasaki, R., Shuto, T., Watanabe, M., Kawahara, T., Suico, M. A., Yokoyama, T., Mizuguchi, M., Kai, H. & Devkota, H. P., 2019/01/30, In: Molecules. 24, 3, , 500.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

7 被引用数 (Scopus)

2020

Neutron diffraction experiment with the Y116S variant of transthyretin using iBIX at J-PARC: Application of a new integration method

Kusaka, K., Yokoyama, T., Yamada, T., Yano, N., Tanaka, I. & Mizuguchi, M., 2020/11/01, In: Acta Crystallographica Section D: Structural Biology. 76, p. 1050-1056 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Structural and thermodynamic analyses of interactions between death-associated protein kinase 1 and anthraquinones

Yokoyama, T., Wijaya, P., Kosaka, Y. & Mizuguchi, M., 2020/05/01, In: Acta Crystallographica Section D: Structural Biology. 76, p. 438-446 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

Transthyretin Amyloidogenesis Inhibitors: From Discovery to Current Developments

Yokoyama, T. & Mizuguchi, M., 2020/12/10, In: Journal of Medicinal Chemistry. 63, 23, p. 14228-14242 15 p.

研究成果: ジャーナルへの寄稿 › 総説 › 査読

30 被引用数 (Scopus)

2021

A chalcone derivative suppresses TSLP induction in mice and human keratinocytes through binding to BET family proteins

Segawa, R., Takeda, H., Yokoyama, T., Ishida, M., Miyata, C., Saito, T., Ishihara, R., Nakagita, T., Sasano, Y., Kanoh, N., Iwabuchi, Y., Mizuguchi, M., Hiratsuka, M. & Hirasawa, N., 2021/12, In: Biochemical Pharmacology. 194, 114819.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

4 被引用数 (Scopus)

A low amyloidogenic E61K transthyretin mutation may cause familial amyloid polyneuropathy

Murakami, T., Yokoyama, T., Mizuguchi, M., Toné, S., Takaku, S., Sango, K., Nishimura, H., Watabe, K. & Sunada, Y., 2021/03, In: Journal of Neurochemistry. 156, 6, p. 957-966 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

Crystal structure of death-associated protein kinase 1 in complex with the dietary compound resveratrol

Yokoyama, T., Suzuki, R. & Mizuguchi, M., 2021, In: IUCrJ. 8, p. 131-138 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

11 被引用数 (Scopus)

Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis

Kitakami, R., Inui, K., Nakagawa, Y., Sawai, Y., Katayama, W., Yokoyama, T., Okada, T., Kanamitsu, K., Nakagawa, S., Toyooka, N. & Mizuguchi, M., 2021/08/15, In: Bioorganic and Medicinal Chemistry. 44, 116292.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

8 被引用数 (Scopus)

Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors

Yokoyama, T., Kashihara, M. & Mizuguchi, M., 2021/10/14, In: Journal of Medicinal Chemistry. 64, 19, p. 14344-14357 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

11 被引用数 (Scopus)

2022

Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis

Mizuguchi, M., Nakagawa, Y., Inui, K., Katayama, W., Sawai, Y., Shimane, A., Kitakami, R., Okada, T., Nabeshima, Y., Yokoyama, T., Kanamitsu, K., Nakagawa, S. & Toyooka, N., 2022/12/22, In: Journal of Medicinal Chemistry. 65, 24, p. 16218-16233 16 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

8 被引用数 (Scopus)

Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP

Yokoyama, T., Fujii, S., Ostermann, A., Schrader, T. E., Nabeshima, Y., Mizuguchi, M. & Smith, J. L., 2022/09/01, In: IUCrJ. 9, Pt 5, p. 562-572 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

3 被引用数 (Scopus)

2023

Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis

Mizuguchi, M., Yokoyama, T., Okada, T., Nakagawa, Y., Fujii, K., Nabeshima, Y. & Toyooka, N., 2023/07/15, In: Bioorganic and Medicinal Chemistry. 90, 117370.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

7 被引用数 (Scopus)

Characterization of the molecular interactions between resveratrol derivatives and death-associated protein kinase 1

Yokoyama, T. & Kusaka, K., 2023/09, In: FEBS Journal. 290, 18, p. 4465-4479 15 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

Combinatorial screening for therapeutics in ATTRv amyloidosis identifies naphthoquinone analogues as TTR-selective amyloid disruptors

Sasaki, R., Suico, M. A., Chosa, K., Teranishi, Y., Sato, T., Kagami, A., Kotani, S., Kato, H., Hitora, Y., Tsukamoto, S., Yamashita, T., Yokoyama, T., Mizuguchi, M., Kai, H. & Shuto, T., 2023/01, In: Journal of Pharmacological Sciences. 151, 1, p. 54-62 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin

Yokoyama, T., Mizuguchi, M., Nabeshima, Y., Nakagawa, Y., Okada, T., Toyooka, N. & Kusaka, K., 2023/11, In: FEBS Journal. 290, 21, p. 5158-5170 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin

Yokoyama, T., Kusaka, K., Mizuguchi, M., Nabeshima, Y. & Fujiwara, S., 2023/11/23, In: Journal of Medicinal Chemistry. 66, 22, p. 15511-15523 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

Structural and mutational analyses of decarboxylated osteocalcin provide insight into its adiponectin-inducing activity

Mizuguchi, M., Yokoyama, T., Otani, T., Kuribara, S., Nabeshima, Y., Obita, T., Hirata, M. & Kawano, K., 2023/06, In: FEBS Letters. 597, 11, p. 1479-1488 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

2024

Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma

Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

4 被引用数 (Scopus)

Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor

Yokoyama, T., Hisatomi, K., Oshima, S., Tanaka, I., Okada, T. & Toyooka, N., 2024/12/05, In: European Journal of Medicinal Chemistry. 279, 116836.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Divergent Total Synthesis of Isoflavone Natural Products and Their Potential as Therapeutic Agents for TTR Amyloidosis

Thanh Luan, N. N., Okada, T., Yokoyama, T., Suzuki, M., Nabeshima, Y., Mizuguchi, M. & Toyooka, N., 2024/11/22, In: Journal of Natural Products. 87, 11, p. 2604-2614 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

SIRT5 mutants reveal the role of conserved asparagine and glutamine residues in the NAD⁺-binding pocket

Yokoyama, T., Takayama, Y., Mizuguchi, M., Nabeshima, Y. & Kusaka, K., 2024/09, In: FEBS Letters. 598, 18, p. 2269-2280 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Structural insights into rapamycin-induced oligomerization of a FRB–FKBP fusion protein

Inobe, T., Sakaguchi, R., Obita, T., Mukaiyama, A., Koike, S., Yokoyama, T., Mizuguchi, M. & Akiyama, S., 2024/09, In: FEBS Letters. 598, 18, p. 2292-2305 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

横山 武司

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横山武司