臨床研究開発推進センター

2025

Analysis of thyroid autoantibodies and the risk of insulin depletion after the clinical onset of acute-onset type 1 diabetes in Japanese patients: the TIDE-J study

Ebisuno, T., Tachibana, M., Imagawa, A., Kanatsuna, N., Terasaki, J., Abiru, N., Awata, T., Ikegami, H., Oikawa, Y., Osawa, H., Katsuki, T., Kawasaki, E., Kozawa, J., Kobayashi, T., Shimada, A., Takahashi, K., Chujo, D., Tsuchiya, K., Nagasawa, K. & Fukui, T. & 4 others, Yasuda, K., Yasuda, H., Kajio, H. & Hanafusa, T., 2025/01, In: Diabetology International. 16, 1, p. 39-49 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Practice guideline: Statement regarding treatment for suspected slowly progressive type 1 diabetes (SPIDDM; probable) cases (English Version)

Shimada, A., Kawasaki, E., Abiru, N., Awata, T., Oikawa, Y., Osawa, H., Kajio, H., Kozawa, J., Takahashi, K., Chujo, D., Noso, S., Fukui, T., Miura, J., Yasuda, K., Yasuda, H., Imagawa, A. & Ikegami, H., 2025/01, In: Diabetology International. 16, 1, p. 1-6 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Practice guideline: Statement regarding treatment for suspected slowly progressive type 1 diabetes (SPIDDM; probable) cases (English version)

Shimada, A., Kawasaki, E., Abiru, N., Awata, T., Oikawa, Y., Osawa, H., Kajio, H., Kozawa, J., Takahashi, K., Chujo, D., Noso, S., Fukui, T., Miura, J., Yasuda, K., Yasuda, H., Imagawa, A. & Ikegami, H., 2025/01, In: Journal of Diabetes Investigation. 16, 1, p. 163-168 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

Role of transforming growth factor-β1 in regulating adipocyte progenitors

Phuong, N. Q., Bilal, M., Nawaz, A., Anh, L. D., Memoona, Aslam, M. R., Khalid, S., Kado, T., Watanabe, Y., Nishimura, A., Igarashi, Y., Okabe, K., Hirabayashi, K., Yamamoto, S., Nakagawa, T., Mori, H., Usui, I., Fujisaka, S., Hayashi, R. & Tobe, K., 2025/12, In: Scientific Reports. 15, 1, 941.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2024

Correction to: New diagnostic criteria (2023) for slowly progressive type 1 diabetes (SPIDDM): Report from Committee on Type 1 Diabetes in Japan Diabetes Society (English version) (Diabetology International, (2024), 15, 1, (1-4), 10.1007/s13340-023-00679-1)

Shimada, A., Kawasaki, E., Abiru, N., Awata, T., Oikawa, Y., Osawa, H., Kajio, H., Kozawa, J., Takahashi, K., Chujo, D., Noso, S., Fukui, T., Miura, J., Yasuda, K., Yasuda, H., Imagawa, A. & Ikegami, H., 2024/07, In: Diabetology International. 15, 3, p. 638-639 2 p.

研究成果: ジャーナルへの寄稿 › コメント/討論

Open Access

1 被引用数 (Scopus)

New diagnostic criteria (2023) for slowly progressive type 1 diabetes (SPIDDM): Report from Committee on Type 1 Diabetes of the Japan Diabetes Society (English version)

Shimada, A., Kawasaki, E., Abiru, N., Awata, T., Oikawa, Y., Osawa, H., Kajio, H., Kozawa, J., Takahashi, K., Chujo, D., Noso, S., Fukui, T., Miura, J., Yasuda, K., Yasuda, H., Imagawa, A. & Ikegami, H., 2024/02, In: Journal of Diabetes Investigation. 15, 2, p. 254-257 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

11 被引用数 (Scopus)

New diagnostic criteria (2023) for slowly progressive type 1 diabetes (SPIDDM): Report from Committee on Type 1 Diabetes in Japan Diabetes Society (English version)

Shimada, A., Kawasaki, E., Abiru, N., Awata, T., Oikawa, Y., Osawa, H., Kajio, H., Kozawa, J., Takahashi, K., Chujo, D., Noso, S., Fukui, T., Miura, J., Yasuda, K., Yasuda, H., Imagawa, A. & Ikegami, H., 2024/01, In: Diabetology International. 15, 1, p. 1-4 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

Prediction of future insulin-deficiency in glutamic acid decarboxylase autoantibody enzyme-linked immunosorbent assay-positive patients with slowly-progressive type 1 diabetes

the Japanese Type 1 Diabetes Database Study (TIDE-J), 2024/07, In: Journal of Diabetes Investigation. 15, 7, p. 835-842 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

Prevention of Recurrent Spontaneous Preterm Delivery Using Probiotics (Clostridium butyricum, Enterococcus faecium, and Bacillus subtilis;PPP Trial): Protocol for a Prospective, Single-Arm, Nonblinded, Multicenter Trial

Yoneda, S., Kobayashi, T., Kikuchi, K., Iwamoto, S., Teramoto, T., Chujo, D., Otsuki, K., Nakai, A. & Saito, S., 2024, In: JMIR Research Protocols. 13, e59928.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Short-term recovery of insulin secretion in response to a meal is associated with future glycemic control in type 2 diabetes patients

Enkaku, A., Chujo, D., Kamigishi, M., Inagawa, S., Matsukoshi, S., Sakai, W., Takikawa, A., Fujisaka, S. & Tobe, K., 2024/04, In: Journal of Diabetes Investigation. 15, 4, p. 437-448 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

2023

Comparing the clinical significance and antigen specificity of insulinoma-associated antigen-2 autoantibodies between radioimmunoassay and enzyme-linked immunosorbent assay in Japanese patients with type 1 diabetes

the Committee of type 1 diabetes, Japan Diabetes Society, 2023/01, In: Journal of Diabetes Investigation. 14, 1, p. 58-66 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

In vivo relationship between bound and free insulin in patients with diabetes having anti-insulin antibodies

Asaka, H., Karashima, S., Chujo, D., Kometani, M., Usukura, M., Yagi, K., Aiga, K. & Yoneda, T., 2023/10, In: Diabetology International. 14, 4, p. 427-433 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Negative correlation between organ heteroplasmy, particularly hepatic heteroplasmy, and age at death revealed by post-mortem studies of m.3243A > G cases

Yagi, K., Okazaki, S., Ohbatake, A., Nakaya, M., Liu, J., Arite, E., Miyamoto, Y., Ito, N., Nakano, K., Yamaaki, N., Honoki, H., Fujisaka, S., Chujo, D., Tsunoda, S. I., Yanagimoto, K., Nozue, T., Yamada, M., Ooe, K., Araki, T. & Nakashima, A. & 9 others, Azami, Y., Sodemoto, Y., Tadokoro, K., Nagano, M., Noguchi, T., Nohara, A., Origasa, H., Niida, Y. & Tada, H., 2023/11, In: Molecular Genetics and Metabolism. 140, 3, 107691.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2 被引用数 (Scopus)

Quality of life after total pancreatectomy with islet autotransplantation for chronic pancreatitis in Japan

Takaki, T., Chujo, D., Kurokawa, T., Kawabe, A., Takahashi, N., Ito, K., Maruyama, K., Inagaki, F., Shinohara, K., Ajima, K., Yamashita, Y., Kajio, H., Yanase, M., Hinohara, C., Tokuhara, M., Uemura, Y., Edamoto, Y., Takemura, N., Kokudo, N. & Matsumoto, S. & 1 others, Shimoda, M., 2023, In: Islets. 15, 1, 2202092.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

3 被引用数 (Scopus)

緩徐進行 1 型糖尿病の診断基準(2023)―1 型糖尿病における新病態の探索的検討委員会報告―

Shimada, A., Kawasaki, E., Abiru, N., Awata, T., Oikawa, Y., Osawa, H., Kajio, H., Kozawa, J., Takahashi, K., Chujo, D., Noso, S., Fukui, T., Miura, J., Yasuda, K., Yasuda, Y., Imagawa, A. & Ikegami, H., 2023, In: Journal of the Japan Diabetes Society. 66, 7, p. 587-591 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

緩徐進行 1 型糖尿病疑い例への治療介入に関するステートメント

Shimada, A., Kawasaki, E., Abiru, N., Awata, T., Oikawa, Y., Osawa, H., Kajio, H., Ozawa, J., Takahashi, K., Chujo, D., Noso, S., Fukui, T., Miura, J., Yasuda, K., Yasuda, Y., Imagawa, A. & Ikegami, H., 2023, In: Journal of the Japan Diabetes Society. 66, 12, p. 807-814 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

2022

Depletion of CD206⁺ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration

Nawaz, A., Bilal, M., Fujisaka, S., Kado, T., Aslam, M. R., Ahmed, S., Okabe, K., Igarashi, Y., Watanabe, Y., Kuwano, T., Tsuneyama, K., Nishimura, A., Nishida, Y., Yamamoto, S., Sasahara, M., Imura, J., Mori, H., Matzuk, M. M., Kudo, F. & Manabe, I. & 4 others, Uezumi, A., Nakagawa, T., Oishi, Y. & Tobe, K., 2022/12, In: Nature Communications. 13, 1, 7058.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

34 被引用数 (Scopus)

Fragmented QRS on electrocardiography as a predictor for diastolic cardiac dysfunction in type 2 diabetes

Yagi, K., Imamura, T., Tada, H., Liu, J., Miyamoto, Y., Ohbatake, A., Ito, N., Shikata, M., Enkaku, A., Takikawa, A., Honoki, H., Fujisaka, S., Chujo, D., Origasa, H., Kinugawa, K. & Tobe, K., 2022/06, In: Journal of Diabetes Investigation. 13, 6, p. 1052-1061 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

2021

Astaxanthin, a marine carotenoid, maintains the tolerance and integrity of adipose tissue and contributes to its healthy functions

Nawaz, A., Nishida, Y., Takikawa, A., Fujisaka, S., Kado, T., Aminuddin, A., Bilal, M., Jeelani, I., Aslam, M. R., Nishimura, A., Kuwano, T., Watanabe, Y., Igarashi, Y., Okabe, K., Ahmed, S., Manzoor, A., Usui, I., Yagi, K., Nakagawa, T. & Tobe, K., 2021/12, In: Nutrients. 13, 12, 4374.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

12 被引用数 (Scopus)

2020

Anti-programmed death ligand 1 therapy-induced type 1 diabetes presenting with multiple islet-related autoantibodies

Honoki, H., Yagi, K., Kambara, K., Chujo, D., Shikata, M., Enkaku, A., Takikawa-Nishida, A., Liu, J., Fujisaka, S. & Tobe, K., 2020/01/01, In: Journal of Diabetes Investigation. 11, 1, p. 253-254 2 p.

研究成果: ジャーナルへの寄稿 › Letter › 査読

Open Access

5 被引用数 (Scopus)

Bofutsushosan improves gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in mice with diet-induced obesity

Fujisaka, S., Usui, I., Nawaz, A., Igarashi, Y., Okabe, K., Furusawa, Y., Watanabe, S., Yamamoto, S., Sasahara, M., Watanabe, Y., Nagai, Y., Yagi, K., Nakagawa, T. & Tobe, K., 2020/12/01, In: Scientific Reports. 10, 1, 5544.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

65 被引用数 (Scopus)

NAD+ Metabolism Regulates Preadipocyte Differentiation by Enhancing α-Ketoglutarate-Mediated Histone H3K9 Demethylation at the PPARγ Promoter

Okabe, K., Nawaz, A., Nishida, Y., Yaku, K., Usui, I., Tobe, K. & Nakagawa, T., 2020/11/24, In: Frontiers in Cell and Developmental Biology. 8, 586179.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

27 被引用数 (Scopus)

2019

Implications of altered NAD metabolism in metabolic disorders

Okabe, K., Yaku, K., Tobe, K. & Nakagawa, T., 2019/05/11, In: Journal of Biomedical Science. 26, 1, 34.

研究成果: ジャーナルへの寄稿 › 総説 › 査読

Open Access

170 被引用数 (Scopus)

Macrophage-specific hypoxia-inducible factor-1α deletion suppresses the development of liver tumors in high-fat diet-fed obese and diabetic mice

Takikawa, A., Usui, I., Fujisaka, S., Tsuneyama, K., Okabe, K., Nakagawa, T., Nawaz, A., Kado, T., Jojima, T., Aso, Y., Hayakawa, Y., Yagi, K. & Tobe, K., 2019/11/01, In: Journal of Diabetes Investigation. 10, 6, p. 1411-1418 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

5 被引用数 (Scopus)

2018

Deletion of PHGDH in adipocytes improves glucose intolerance in diet-induced obese mice

Okabe, K., Usui, I., Yaku, K., Hirabayashi, Y., Tobe, K. & Nakagawa, T., 2018/09/26, In: Biochemical and Biophysical Research Communications. 504, 1, p. 309-314 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

11 被引用数 (Scopus)

Erratum to: Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice (Scientific Reports, (2018), 8, 1, (11370), 10.1038/s41598-018-29773-0)

Nawaz, A., Mehmood, A., Kanatani, Y., Kado, T., Igarashi, Y., Takikawa, A., Yamamoto, S., Okabe, K., Nakagawa, T., Yagi, K., Fujisaka, S. & Tobe, K., 2018/12/01, In: Scientific Reports. 8, 1, 14597.

研究成果: ジャーナルへの寄稿 › コメント/討論

Open Access

1 被引用数 (Scopus)

High frequency of type 2 diabetes and impaired glucose tolerance in Japanese subjects with the angiopoietin-like protein 8 R59W variant

Liu, J., Yagi, K., Nohara, A., Chujo, D., Ohbatake, A., Fujimoto, A., Miyamoto, Y., Kobayashi, J. & Yamagishi, M., 2018/03/01, In: Journal of Clinical Lipidology. 12, 2, p. 331-337 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

19 被引用数 (Scopus)

NAD metabolism in cancer therapeutics

Yaku, K., Okabe, K., Hikosaka, K. & Nakagawa, T., 2018, In: Frontiers in Oncology. 8, DEC, 622.

研究成果: ジャーナルへの寄稿 › 総説 › 査読

Open Access

167 被引用数 (Scopus)

Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance

Gulshan, M., Yaku, K., Okabe, K., Mahmood, A., Sasaki, T., Yamamoto, M., Hikosaka, K., Usui, I., Kitamura, T., Tobe, K. & Nakagawa, T., 2018/08, In: Aging Cell. 17, 4, e12798.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

40 被引用数 (Scopus)

2016

HIF-1α in myeloid cells promotes adipose tissue remodeling toward insulin resistance

Takikawa, A., Mahmood, A., Nawaz, A., Kado, T., Okabe, K., Yamamoto, S., Aminuddin, A., Senda, S., Tsuneyama, K., Ikutani, M., Watanabe, Y., Igarashi, Y., Nagai, Y., Takatsu, K., Koizumi, K., Imura, J., Goda, N., Sasahara, M., Matsumoto, M. & Saeki, K. & 4 others, Nakagawa, T., Fujisaka, S., Usui, I. & Tobe, K., 2016/12/01, In: Diabetes. 65, 12, p. 3649-3659 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

95 被引用数 (Scopus)

2014

Secretory units of islets in transplantation index is a useful predictor of insulin requirement in Japanese type 2 diabetic patients

Iwata, M., Matsushita, Y., Fukuda, K., Wakura, T., Okabe, K., Koshimizu, Y., Fukushima, Y., Kobashi, C., Yamazaki, Y., Honoki, H., Suzuki, H., Kigawa, M. & Tobe, K., 2014, In: Journal of Diabetes Investigation. 5, 5, p. 570-580 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

27 被引用数 (Scopus)

臨床研究開発推進センター

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