和漢医薬学総合研究所研究開発部門複雑系解析分野

Keyphrases

1. Sterol Regulatory Element-binding protein-1c (SREBP-1c) 100%
2. Liver 59%
3. Obesity 31%
4. PRMT1 30%
5. Gene Expression 30%
6. ELOVL6 30%
7. Peroxisome Proliferator-activated Receptor 29%
8. Transcription Factor 29%
9. Adipocyte 28%
10. Transgenic Mice 28%
11. Insulin Resistance 25%
12. Macrophages 23%
13. Lipid Metabolism 23%
14. White Adipose Tissue 22%
15. Knock-in Mouse Model 22%
16. Diabetes 21%
17. CAMP-responsive Element Binding Protein 19%
18. Protein Tyrosine Phosphatase 1B (PTP1B) 18%
19. Fibroblast Growth Factor 21 (FGF21) 17%
20. CREBH 17%
21. Transcription Factor E3 (TFE3) 16%
22. High-fat Diet 16%
23. Low-density Lipoprotein Receptor 16%
24. Glucose Metabolism 16%
25. Overexpressing 13%
26. Insulin Signaling 13%
27. Diet-induced Obesity 13%
28. Diet-induced 13%
29. Insulin 13%
30. Overexpression 13%
31. Islet 13%
32. Pancreatic Islets 12%
33. Insulin Secretion 12%
34. Pancreatic Cells 12%
35. IRS2 12%
36. Pemafibrate 11%
37. Microvesicles 11%
38. Type 2 Diabetes Mellitus (T2DM) 11%
39. Hepatocytes 11%
40. Molecular Mechanism 11%
41. MicroRNA 11%
42. Refeeding 11%
43. Fatty Acids 11%
44. Lipogenesis 10%
45. Protein Kinase 10%
46. Cell Behavior 10%
47. Fatty Acid Oxidation 10%
48. Lipolysis 9%
49. CtBP 9%
50. Cyclin-dependent Kinase Inhibitor 9%
51. Caloric Restriction 9%
52. Lipid Synthesis 9%
53. Impaired Insulin Secretion 9%
54. Adipocyte Differentiation 9%
55. Gene-deficient Mice 9%
56. Liver X Receptor 9%
57. Obese Mice 8%
58. Fatty Acid Synthase 8%
59. Positive Emotions 8%
60. Transforming Growth Factor-β 8%
61. Cholesterol 8%
62. Non-alcoholic Fatty Liver Disease (NAFLD) 8%
63. Receptor Modulators 8%
64. Cell Mass 8%
65. Lung 8%
66. Adipose Tissue 8%
67. Small Intestine 8%
68. Whole-body 8%
69. PGC-1 8%
70. Cell Survival 8%
71. K-877 8%
72. Skeletal muscle 8%
73. Diabetic 8%
74. 3T3-L1 Adipocytes 7%
75. Knockdown 7%
76. PRMT8 7%
77. PPAR Modulators 7%
78. Vascular Smooth muscle Cells 7%
79. Neurocircuitry 7%
80. Pulmonary Fibrosis 7%
81. Ovarian Granulosa Cells 7%
82. Insulin Sensitivity 7%
83. Fatty Liver 7%
84. Db Mouse 7%
85. Statins 7%
86. C-Src 6%
87. Mouse Liver 6%
88. Triglycerides 6%
89. Nonalcoholic Steatohepatitis 6%
90. Fibrosis 6%
91. Hepatosteatosis 6%
92. Palmitate 6%
93. Vascular Endothelial Cells 6%
94. Idiopathic Pulmonary Fibrosis 6%
95. Mouse Model 6%
96. Promoter Analysis 6%
97. Endoplasmic Reticulum Stress (ER stress) 6%
98. Changes in Gene Expression 6%
99. Liver-specific 6%
100. Polyunsaturated Fatty Acids 6%

Biochemistry, Genetics and Molecular Biology

1. Sterol Regulatory Element Binding Protein 1c 45%
2. Adipocyte 43%
3. Transcription Factors 42%
4. Gene Expression 41%
5. Binding Protein 32%
6. Insulin Resistance 29%
7. Methyltransferase 29%
8. Arginine 29%
9. Sterol Regulatory Element Binding Protein 1 28%
10. Promoter Region 27%
11. Lipid Metabolism 27%
12. Transgenic Mouse 25%
13. Peroxisome Proliferator-Activated Receptor 25%
14. Sterol Regulatory Element-Binding Protein 24%
15. Lipogenesis 24%
16. Insulin Release 22%
17. Knockout Mouse 21%
18. Triglyceride 21%
19. FGF21 21%
20. Cyclic Adenosine Monophosphate 20%
21. Enzyme 19%
22. Sterol Regulatory Element Binding Protein 1a 19%
23. Hepatocyte 19%
24. Glucose Metabolism 17%
25. Protein Tyrosine Phosphatase 15%
26. C-Terminus 15%
27. Macrophage 14%
28. Cell Function 14%
29. Insulin Signaling 13%
30. Skeletal Muscle 12%
31. Mouse Mutant 12%
32. Wild Type 12%
33. P53 12%
34. Microvesicles 11%
35. MicroRNA 11%
36. 3T3-L1 11%
37. Messenger RNA 11%
38. Small Intestine 10%
39. Upregulation 10%
40. Blood Plasma 9%
41. Cyclin-Dependent Kinase 9%
42. Oxidative Stress 9%
43. Lipolysis 9%
44. Lipid Composition 9%
45. Insulin Receptor 9%
46. Methylation 9%
47. Cancer Growth Factor 9%
48. Lipid 8%
49. Liver X Receptor 8%
50. Palmitic Acid 8%
51. LDL Receptor 8%
52. Cell Survival 8%
53. Homeostasis 8%
54. Insulin Sensitivity 7%
55. Transcriptomics 7%
56. Endoplasmic Reticulum Stress 7%
57. Metabolic Pathway 7%
58. Ob/Ob Mouse 7%
59. N-Terminus 7%
60. Oncogene Src 7%
61. Beta Oxidation 7%
62. Hyperlipidemia 7%
63. Leptin 7%
64. Sucrose 6%
65. P21 6%
66. Polyunsaturated Fatty Acid 6%
67. Lipotoxicity 6%
68. Fibroblast 6%
69. Cell Growth 6%
70. Gluconeogenesis 6%
71. Db/Db Mouse 6%
72. Gene Expression Profiling 6%
73. Transcription 6%
74. Thermogenesis 5%
75. TFE3 5%
76. Glycemic Control 5%
77. Enhancer Region 5%
78. Corepressor 5%
79. Mouse Model 5%
80. Hypertriglyceridemia 5%
81. Fatty Acid Synthesis 5%
82. Saturated Fatty Acid 5%
83. Wild Type Mouse 5%
84. Elongase 5%
85. Mitochondrial Biogenesis 5%
86. Streptozotocin 5%
87. Animal Model 5%
88. Caenorhabditis Elegans 5%
89. Lipid Storage 5%