@article{318c81fb3c8345fc82bf74dd35b83890,
title = "Yoropyrazone, a new naphthopyridazone alkaloid isolated from Streptomyces sp. IFM 11307 and evaluation of its TRAIL resistance-overcoming activity",
abstract = "A new naphthopyridazone derivative, yoropyrazone (1), has been isolated from Streptomyces sp. IFM 11307. The structure of the new compound was established on the basis of spectroscopic analyses. Compound 1 (10 M) in combination with TRAIL moderately showed cytotoxic activity in sensitizing TRAIL-resistant human gastric adenocarcinoma (AGS) cells.",
keywords = "Streptomyces sp., TRAIL, naphthopyridazone",
author = "Abdelfattah, {Mohamed S.} and Kazufumi Toume and Masami Ishibashi",
note = "Funding Information: We thank Professor Tohru Gonoi (Medical Mycology Research Center, Chiba University) for the identification of Streptomyces sp. IFM 11307. The research was supported by a Grant-in-Aid (22310133 and 23404007) for Scientific Research from the Japan Society for the Promotion of Science, a Grant-in-Aid (23102008) for Scientific Research on Innovative Areas {\textquoteleft}Chemical Biology of Natural Products{\textquoteright} from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT), Special Funds for Education and Research (Development of SPECT Probes for Pharmaceutical Innovation) from MEXT, the Iodine Research Project in Chiba University, and the Asian Core Program (JSPS). MS Abdelfattah thanks JSPS for a postdoctoral fellowship (ID No. P09042).",
year = "2012",
month = may,
doi = "10.1038/ja.2012.11",
language = "英語",
volume = "65",
pages = "245--248",
journal = "Journal of Antibiotics",
issn = "0021-8820",
publisher = "Springer Nature",
number = "5",
}