TY - JOUR
T1 - Volumetric MRI study of the short and long insular cortices in schizophrenia spectrum disorders
AU - Takahashi, Tsutomu
AU - Suzuki, Michio
AU - Zhou, Shi Yu
AU - Hagino, Hirofumi
AU - Tanino, Ryoichiro
AU - Kawasaki, Yasuhiro
AU - Nohara, Shigeru
AU - Yamashita, Ikiko
AU - Seto, Hikaru
AU - Kurachi, Masayoshi
N1 - Funding Information:
This study was supported in part by Grant-in-Aid for Young Scientists 16790678 from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and a Research Grant (11-3) for Nervous and Mental Disorders from the Ministry of Health and Welfare, Japan.
PY - 2005/4/30
Y1 - 2005/4/30
N2 - We have previously reported volume reductions of the insular cortex in schizophrenia, but it is still not clear whether insular cortex volume loss preferentially involves the anterior (short insular cortex) or posterior (long insular cortex) portion. On the other hand, no volumetric studies of the brain have examined changes in insular cortex volume in subjects with schizotypal features. In this study, we separately investigated the volumes of the short and long insular cortex portions using magnetic resonance imaging in 37 schizotypal disorder patients (24 males, 13 females), 62 schizophrenia patients (32 males, 30 females), and 69 healthy controls (35 males, 34 females). While the volumes of the short and long insular cortex were significantly reduced in schizophrenia patients compared with schizotypal disorder patients and control subjects, there was no difference between schizotypal disorder patients and control subjects. These results suggest that the volume reduction of the insular cortex may be specific to overt schizophrenia without topographically specific localization.
AB - We have previously reported volume reductions of the insular cortex in schizophrenia, but it is still not clear whether insular cortex volume loss preferentially involves the anterior (short insular cortex) or posterior (long insular cortex) portion. On the other hand, no volumetric studies of the brain have examined changes in insular cortex volume in subjects with schizotypal features. In this study, we separately investigated the volumes of the short and long insular cortex portions using magnetic resonance imaging in 37 schizotypal disorder patients (24 males, 13 females), 62 schizophrenia patients (32 males, 30 females), and 69 healthy controls (35 males, 34 females). While the volumes of the short and long insular cortex were significantly reduced in schizophrenia patients compared with schizotypal disorder patients and control subjects, there was no difference between schizotypal disorder patients and control subjects. These results suggest that the volume reduction of the insular cortex may be specific to overt schizophrenia without topographically specific localization.
KW - Insula
KW - Magnetic resonance imaging
KW - Schizophrenia
KW - Schizotypal disorder
UR - http://www.scopus.com/inward/record.url?scp=20944442085&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2005.02.004
DO - 10.1016/j.pscychresns.2005.02.004
M3 - 学術論文
C2 - 15854789
AN - SCOPUS:20944442085
SN - 0925-4927
VL - 138
SP - 209
EP - 220
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 3
ER -
