TY - JOUR
T1 - Volume reduction of the right anterior limb of the internal capsule in patients with schizotypal disorder
AU - Suzuki, Michio
AU - Zhou, Shi Yu
AU - Hagino, Hirofumi
AU - Takahashi, Tsutomu
AU - Kawasaki, Yasuhiro
AU - Nohara, Shigeru
AU - Yamashita, Ikiko
AU - Matsui, Mie
AU - Seto, Hikaru
AU - Kurachi, Masayoshi
N1 - Funding Information:
This research was supported by the grants from the Japanese Ministry of Health, Labour and Welfare (11-3-02), the Japan Society for the Promotion of Science (12470193), and the Japan Foundation for Aging and Health (03120085).
PY - 2004/4/30
Y1 - 2004/4/30
N2 - We have previously reported bilateral volume reductions in the anterior limb of the internal capsule (ALIC) in patients with schizophrenia. The purpose of this study was to extend the volumetric measurements of ALIC to subjects with schizotypal features to explore the neurobiology underlying schizophrenia-spectrum disorders in view of the fronto-thalamic connectivity. Three-dimensional magnetic resonance images were acquired from 24 patients with schizotypal disorder (ICD-10) and 47 healthy volunteers matched for age, gender, handedness, and parental education. Volumetric analyses of the ALIC and anterior parts of the caudate and lentiform nuclei were conducted using consecutive 1-mm thick coronal slices rostral to the anterior commissure. Compared with the comparison subjects, the schizotypal patients had significantly decreased volume in the right ALIC, but there was no significant group difference in the left ALIC volume. Volumes of the anterior part of the caudate or lentiform nucleus did not differ between groups. Volume deficit confined to the right ALIC suggests that limited involvement of the fronto-thalamic connectivity may have some relevance to the sparing of schizotypal patients from the development of overt psychosis.
AB - We have previously reported bilateral volume reductions in the anterior limb of the internal capsule (ALIC) in patients with schizophrenia. The purpose of this study was to extend the volumetric measurements of ALIC to subjects with schizotypal features to explore the neurobiology underlying schizophrenia-spectrum disorders in view of the fronto-thalamic connectivity. Three-dimensional magnetic resonance images were acquired from 24 patients with schizotypal disorder (ICD-10) and 47 healthy volunteers matched for age, gender, handedness, and parental education. Volumetric analyses of the ALIC and anterior parts of the caudate and lentiform nuclei were conducted using consecutive 1-mm thick coronal slices rostral to the anterior commissure. Compared with the comparison subjects, the schizotypal patients had significantly decreased volume in the right ALIC, but there was no significant group difference in the left ALIC volume. Volumes of the anterior part of the caudate or lentiform nucleus did not differ between groups. Volume deficit confined to the right ALIC suggests that limited involvement of the fronto-thalamic connectivity may have some relevance to the sparing of schizotypal patients from the development of overt psychosis.
KW - Anterior limb of internal capsule
KW - Fronto-thalamic connectivity
KW - Magnetic resonance imaging
KW - Schizotypal disorder
KW - Volumetry
UR - http://www.scopus.com/inward/record.url?scp=2342654310&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2004.01.001
DO - 10.1016/j.pscychresns.2004.01.001
M3 - 学術論文
C2 - 15135156
AN - SCOPUS:2342654310
SN - 0925-4927
VL - 130
SP - 213
EP - 225
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 3
ER -
