Vitamin K2 ameliorates experimental autoimmune encephalomyelitis in Lewis rats

Masayuki Moriya; Yuji Nakatsuji; Tatsusada Okuno; Toshimitsu Hamasaki; Makoto Sawada; Saburo Sakoda

doi:10.1016/j.jneuroim.2005.08.001

Vitamin K₂ ameliorates experimental autoimmune encephalomyelitis in Lewis rats

Masayuki Moriya, Yuji Nakatsuji, Tatsusada Okuno, Toshimitsu Hamasaki, Makoto Sawada, Saburo Sakoda^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Vitamin K₂ (VK2), which has been in wide use for the management of hypoprothrombinemia and osteoporosis in Japan, was tested for its efficacy on experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). The severity of EAE was significantly ameliorated by the prophylactic administration of VK2, though it was not effective when given after the onset. Inflammatory cellular infiltration and the expression of both MHC class II and inducible nitric oxide synthase (iNOS) were reduced in the spinal cords of VK2-treated rats with EAE. The inhibitory effect of VK2 on the iNOS expression in glial cells was also observed in vitro. Considering the long use of VK2 without noticeable untoward effects, it may be applicable to the patients with MS.

Original language	English
Pages (from-to)	11-20
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	170
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2005.08.001
State	Published - 2005/12/30

Keywords

Experimental autoimmune encephalomyelitis
Inducible nitric oxide synthase
MHC class II
Vitamin K

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/j.jneuroim.2005.08.001

Cite this

@article{67f5db80f3c14620aa9b3187b3b31687,

title = "Vitamin K2 ameliorates experimental autoimmune encephalomyelitis in Lewis rats",

abstract = "Vitamin K2 (VK2), which has been in wide use for the management of hypoprothrombinemia and osteoporosis in Japan, was tested for its efficacy on experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). The severity of EAE was significantly ameliorated by the prophylactic administration of VK2, though it was not effective when given after the onset. Inflammatory cellular infiltration and the expression of both MHC class II and inducible nitric oxide synthase (iNOS) were reduced in the spinal cords of VK2-treated rats with EAE. The inhibitory effect of VK2 on the iNOS expression in glial cells was also observed in vitro. Considering the long use of VK2 without noticeable untoward effects, it may be applicable to the patients with MS.",

keywords = "Experimental autoimmune encephalomyelitis, Inducible nitric oxide synthase, MHC class II, Vitamin K",

author = "Masayuki Moriya and Yuji Nakatsuji and Tatsusada Okuno and Toshimitsu Hamasaki and Makoto Sawada and Saburo Sakoda",

note = "Funding Information: The authors thank Dr. Yoshinobu Okuda for helpful suggestions. This study was partly supported by Eisai Co., Ltd (Tokyo, Japan).",

year = "2005",

month = dec,

day = "30",

doi = "10.1016/j.jneuroim.2005.08.001",

language = "英語",

volume = "170",

pages = "11--20",

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issn = "0165-5728",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Vitamin K2 ameliorates experimental autoimmune encephalomyelitis in Lewis rats

AU - Moriya, Masayuki

AU - Nakatsuji, Yuji

AU - Okuno, Tatsusada

AU - Hamasaki, Toshimitsu

AU - Sawada, Makoto

AU - Sakoda, Saburo

N1 - Funding Information: The authors thank Dr. Yoshinobu Okuda for helpful suggestions. This study was partly supported by Eisai Co., Ltd (Tokyo, Japan).

PY - 2005/12/30

Y1 - 2005/12/30

N2 - Vitamin K2 (VK2), which has been in wide use for the management of hypoprothrombinemia and osteoporosis in Japan, was tested for its efficacy on experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). The severity of EAE was significantly ameliorated by the prophylactic administration of VK2, though it was not effective when given after the onset. Inflammatory cellular infiltration and the expression of both MHC class II and inducible nitric oxide synthase (iNOS) were reduced in the spinal cords of VK2-treated rats with EAE. The inhibitory effect of VK2 on the iNOS expression in glial cells was also observed in vitro. Considering the long use of VK2 without noticeable untoward effects, it may be applicable to the patients with MS.

AB - Vitamin K2 (VK2), which has been in wide use for the management of hypoprothrombinemia and osteoporosis in Japan, was tested for its efficacy on experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). The severity of EAE was significantly ameliorated by the prophylactic administration of VK2, though it was not effective when given after the onset. Inflammatory cellular infiltration and the expression of both MHC class II and inducible nitric oxide synthase (iNOS) were reduced in the spinal cords of VK2-treated rats with EAE. The inhibitory effect of VK2 on the iNOS expression in glial cells was also observed in vitro. Considering the long use of VK2 without noticeable untoward effects, it may be applicable to the patients with MS.

KW - Experimental autoimmune encephalomyelitis

KW - Inducible nitric oxide synthase

KW - MHC class II

KW - Vitamin K

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DO - 10.1016/j.jneuroim.2005.08.001

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JO - Journal of Neuroimmunology

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