Vicarious nucleophilic substitution of pyridazinium N-dicyanomethylides

Takashi Itoh; Yûji Matsuya; Kazuhiro Nagata; Michiko Miyazaki; Nozomi Tsutsumi; Akio Ohsawa

doi:10.1039/a800733k

Vicarious nucleophilic substitution of pyridazinium N-dicyanomethylides

Takashi Itoh, Yûji Matsuya, Kazuhiro Nagata, Michiko Miyazaki, Nozomi Tsutsumi, Akio Ohsawa^*

^*Corresponding author for this work

Synthetic and Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Pyridazines have been allowed to react with tetracyanoethylene oxide to give pyridazinium N-dicyanomethylides, which are subjected to vicarious nucleophilic substitution to afford the corresponding 4-substituted derivatives in moderate to good yields. The dicyanomethylene group is readily eliminated by a radical reaction, and 4-substituted pyridazines are obtained.

Original language	English
Pages (from-to)	1637-1641
Number of pages	5
Journal	Journal of the Chemical Society - Perkin Transactions 1
Issue number	10
DOIs	https://doi.org/10.1039/a800733k
State	Published - 1998/05/21

ASJC Scopus subject areas

General Chemistry

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title = "Vicarious nucleophilic substitution of pyridazinium N-dicyanomethylides",

abstract = "Pyridazines have been allowed to react with tetracyanoethylene oxide to give pyridazinium N-dicyanomethylides, which are subjected to vicarious nucleophilic substitution to afford the corresponding 4-substituted derivatives in moderate to good yields. The dicyanomethylene group is readily eliminated by a radical reaction, and 4-substituted pyridazines are obtained.",

author = "Takashi Itoh and Y{\^u}ji Matsuya and Kazuhiro Nagata and Michiko Miyazaki and Nozomi Tsutsumi and Akio Ohsawa",

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AU - Itoh, Takashi

AU - Matsuya, Yûji

AU - Nagata, Kazuhiro

AU - Miyazaki, Michiko

AU - Tsutsumi, Nozomi

AU - Ohsawa, Akio

PY - 1998/5/21

Y1 - 1998/5/21

N2 - Pyridazines have been allowed to react with tetracyanoethylene oxide to give pyridazinium N-dicyanomethylides, which are subjected to vicarious nucleophilic substitution to afford the corresponding 4-substituted derivatives in moderate to good yields. The dicyanomethylene group is readily eliminated by a radical reaction, and 4-substituted pyridazines are obtained.

AB - Pyridazines have been allowed to react with tetracyanoethylene oxide to give pyridazinium N-dicyanomethylides, which are subjected to vicarious nucleophilic substitution to afford the corresponding 4-substituted derivatives in moderate to good yields. The dicyanomethylene group is readily eliminated by a radical reaction, and 4-substituted pyridazines are obtained.

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DO - 10.1039/a800733k

M3 - 学術論文

AN - SCOPUS:33748479480

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EP - 1641

JO - Journal of the Chemical Society - Perkin Transactions 1

JF - Journal of the Chemical Society - Perkin Transactions 1

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Vicarious nucleophilic substitution of pyridazinium N-dicyanomethylides

Abstract

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