TY - JOUR
T1 - Various factors contribute to death in patients with different types of pulmonary hypertension
T2 - A retrospective pilot study from a single tertiary center
AU - Nakamura, Junichi
AU - Tsujino, Ichizo
AU - Ohira, Hiroshi
AU - Nakaya, Toshitaka
AU - Sugimoto, Ayako
AU - Sato, Takahiro
AU - Watanabe, Taku
AU - Suzuki, Masaru
AU - Kato, Masaru
AU - Yokota, Isao
AU - Konno, Satoshi
N1 - Publisher Copyright:
© 2022 The Japanese Respiratory Society
PY - 2022/9
Y1 - 2022/9
N2 - Background: A few studies have focused on the cause of death from different types of pulmonary hypertension (PH). This study aimed to systematically analyze the primary and secondary causes of death and compare the profiles between different PH groups. Methods: The contribution of PH to death was assessed in precapillary PH (i.e., group 1 [pulmonary arterial hypertension], group 3 [PH associated with lung disease], and group 4 [chronic thromboembolic PH]) using specific criteria; death was classified into three categories: PH death (death due to PH only), PH-related death, and PH-unrelated death. Disorders other than PH that contributed to death were analyzed, and mortality profiles were compared between groups. Results: Eighty deceased patients with PH were examined (group 1, n = 28; group 3, n = 39; and group 4, n = 13). The contribution of PH to death was significantly different between the three groups. “PH death” was most common in group 1 (61%), “PH-related death” in group 3 (56%), and “PH-related death” and “PH-unrelated death” in group 4 (38% for both). The highest contributing factor to death other than PH was respiratory failure in group 3 and malignant disease in group 4. Conclusions: Significant variations in the causes of death were observed in groups 1, 3, and 4 PH patients. In addition to PH, respiratory failure and malignant disease significantly contributed to death in group 3 and group 4 PH, respectively. Understanding the precise death cause may be important in achieving better outcomes in PH patients.
AB - Background: A few studies have focused on the cause of death from different types of pulmonary hypertension (PH). This study aimed to systematically analyze the primary and secondary causes of death and compare the profiles between different PH groups. Methods: The contribution of PH to death was assessed in precapillary PH (i.e., group 1 [pulmonary arterial hypertension], group 3 [PH associated with lung disease], and group 4 [chronic thromboembolic PH]) using specific criteria; death was classified into three categories: PH death (death due to PH only), PH-related death, and PH-unrelated death. Disorders other than PH that contributed to death were analyzed, and mortality profiles were compared between groups. Results: Eighty deceased patients with PH were examined (group 1, n = 28; group 3, n = 39; and group 4, n = 13). The contribution of PH to death was significantly different between the three groups. “PH death” was most common in group 1 (61%), “PH-related death” in group 3 (56%), and “PH-related death” and “PH-unrelated death” in group 4 (38% for both). The highest contributing factor to death other than PH was respiratory failure in group 3 and malignant disease in group 4. Conclusions: Significant variations in the causes of death were observed in groups 1, 3, and 4 PH patients. In addition to PH, respiratory failure and malignant disease significantly contributed to death in group 3 and group 4 PH, respectively. Understanding the precise death cause may be important in achieving better outcomes in PH patients.
KW - Cancer
KW - Respiratory failure
KW - Right heart failure
KW - Sudden death
UR - http://www.scopus.com/inward/record.url?scp=85130784081&partnerID=8YFLogxK
U2 - 10.1016/j.resinv.2022.05.001
DO - 10.1016/j.resinv.2022.05.001
M3 - 学術論文
C2 - 35644802
AN - SCOPUS:85130784081
SN - 2212-5345
VL - 60
SP - 647
EP - 657
JO - Respiratory Investigation
JF - Respiratory Investigation
IS - 5
ER -