Two distinct enriched housings differentially ameliorate object and place recognition deficits in a rat model of schizophrenia

Michimasa Toyoshima; Katsumasa Takahashi; Eri Sato; Shota Shimoda; Kazuo Yamada

doi:10.1016/j.bbr.2024.115276

Two distinct enriched housings differentially ameliorate object and place recognition deficits in a rat model of schizophrenia

Michimasa Toyoshima, Katsumasa Takahashi, Eri Sato, Shota Shimoda, Kazuo Yamada^*

^*Corresponding author for this work

Systems Function & Morphology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Schizophrenia is a psychiatric disorder characterized by cognitive dysfunctions. These dysfunctions significantly impact the daily lives of schizophrenic patients, yet effective interventions remain scarce. In this study, we explored the effects of two enriched housing types—cognitive and physical—on cognitive dysfunctions in a rat model of schizophrenia. Male neonatal Wistar-Imamichi rats were administered MK-801, a noncompetitive NMDAR antagonist, twice daily from postnatal day (PND) 7 to PND 20. Physical enrichment ameliorated memory deficits in both object and place recognition tests, while cognitive enrichment primarily improved object recognition performance. Our findings suggest that exercise therapy could be a potential approach to address cognitive dysfunctions in schizophrenia patients.

Original language	English
Article number	115276
Journal	Behavioural Brain Research
Volume	476
DOIs	https://doi.org/10.1016/j.bbr.2024.115276
State	Published - 2025/01/05

Keywords

Enriched housing
Neonatal MK-801 treatment
Object recognition
Place recognition
Rats

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/j.bbr.2024.115276

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title = "Two distinct enriched housings differentially ameliorate object and place recognition deficits in a rat model of schizophrenia",

abstract = "Schizophrenia is a psychiatric disorder characterized by cognitive dysfunctions. These dysfunctions significantly impact the daily lives of schizophrenic patients, yet effective interventions remain scarce. In this study, we explored the effects of two enriched housing types—cognitive and physical—on cognitive dysfunctions in a rat model of schizophrenia. Male neonatal Wistar-Imamichi rats were administered MK-801, a noncompetitive NMDAR antagonist, twice daily from postnatal day (PND) 7 to PND 20. Physical enrichment ameliorated memory deficits in both object and place recognition tests, while cognitive enrichment primarily improved object recognition performance. Our findings suggest that exercise therapy could be a potential approach to address cognitive dysfunctions in schizophrenia patients.",

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AU - Toyoshima, Michimasa

AU - Takahashi, Katsumasa

AU - Sato, Eri

AU - Shimoda, Shota

AU - Yamada, Kazuo

PY - 2025/1/5

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N2 - Schizophrenia is a psychiatric disorder characterized by cognitive dysfunctions. These dysfunctions significantly impact the daily lives of schizophrenic patients, yet effective interventions remain scarce. In this study, we explored the effects of two enriched housing types—cognitive and physical—on cognitive dysfunctions in a rat model of schizophrenia. Male neonatal Wistar-Imamichi rats were administered MK-801, a noncompetitive NMDAR antagonist, twice daily from postnatal day (PND) 7 to PND 20. Physical enrichment ameliorated memory deficits in both object and place recognition tests, while cognitive enrichment primarily improved object recognition performance. Our findings suggest that exercise therapy could be a potential approach to address cognitive dysfunctions in schizophrenia patients.

AB - Schizophrenia is a psychiatric disorder characterized by cognitive dysfunctions. These dysfunctions significantly impact the daily lives of schizophrenic patients, yet effective interventions remain scarce. In this study, we explored the effects of two enriched housing types—cognitive and physical—on cognitive dysfunctions in a rat model of schizophrenia. Male neonatal Wistar-Imamichi rats were administered MK-801, a noncompetitive NMDAR antagonist, twice daily from postnatal day (PND) 7 to PND 20. Physical enrichment ameliorated memory deficits in both object and place recognition tests, while cognitive enrichment primarily improved object recognition performance. Our findings suggest that exercise therapy could be a potential approach to address cognitive dysfunctions in schizophrenia patients.

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Two distinct enriched housings differentially ameliorate object and place recognition deficits in a rat model of schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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