Two cases of thiopurine-induced acute pancreatitis in inflammatory bowel disease

Jun Nishikawa; Takahiko Kudo; Takako Miyazaki; Hiroshi Mihara; Akira Ueda; Takayuki Ando; Shinya Kajiura; Haruka Fujinami; Kohei Ogawa; Ayumu Hosokawa; Toshiro Sugiyama

Two cases of thiopurine-induced acute pancreatitis in inflammatory bowel disease

Jun Nishikawa^*, Takahiko Kudo, Takako Miyazaki, Hiroshi Mihara, Akira Ueda, Takayuki Ando, Shinya Kajiura, Haruka Fujinami, Kohei Ogawa, Ayumu Hosokawa, Toshiro Sugiyama

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Thiopurine drugs have been widely used in the treatment of inflammatory bowel disease. However, their use is limited by adverse effect that can lead to cessation of therapy. We report 2 cases of thiopurine-induced acute pancreatitis in patients with inflammatory bowel disease. Both patients complained of abdominal pain, showed elevated pancreatic enzymes, and swollen pancreases on computed tomography. The patients' signs and symptoms resolved uneventfully after withdrawal of the thiopurine drugs. Although the mechanism of thiopurine-induced pancreatitis remains unclear, close monitoring and early recognition of acute pancreatitis is important in the management of new thiopurine users.

Original language	English
Pages (from-to)	224-230
Number of pages	7
Journal	Journal of Japanese Society of Gastroenterology
Volume	109
Issue number	2
State	Published - 2012/02

ASJC Scopus subject areas

Gastroenterology

Cite this

@article{b8b99f97f037474c9507da24d0b9f2de,

title = "Two cases of thiopurine-induced acute pancreatitis in inflammatory bowel disease",

abstract = "Thiopurine drugs have been widely used in the treatment of inflammatory bowel disease. However, their use is limited by adverse effect that can lead to cessation of therapy. We report 2 cases of thiopurine-induced acute pancreatitis in patients with inflammatory bowel disease. Both patients complained of abdominal pain, showed elevated pancreatic enzymes, and swollen pancreases on computed tomography. The patients' signs and symptoms resolved uneventfully after withdrawal of the thiopurine drugs. Although the mechanism of thiopurine-induced pancreatitis remains unclear, close monitoring and early recognition of acute pancreatitis is important in the management of new thiopurine users.",

author = "Jun Nishikawa and Takahiko Kudo and Takako Miyazaki and Hiroshi Mihara and Akira Ueda and Takayuki Ando and Shinya Kajiura and Haruka Fujinami and Kohei Ogawa and Ayumu Hosokawa and Toshiro Sugiyama",

year = "2012",

month = feb,

language = "英語",

volume = "109",

pages = "224--230",

journal = "Journal of Japanese Society of Gastroenterology",

issn = "0446-6586",

publisher = "Japanese Society of Gastroenterology",

number = "2",

}

TY - JOUR

T1 - Two cases of thiopurine-induced acute pancreatitis in inflammatory bowel disease

AU - Nishikawa, Jun

AU - Kudo, Takahiko

AU - Miyazaki, Takako

AU - Mihara, Hiroshi

AU - Ueda, Akira

AU - Ando, Takayuki

AU - Kajiura, Shinya

AU - Fujinami, Haruka

AU - Ogawa, Kohei

AU - Hosokawa, Ayumu

AU - Sugiyama, Toshiro

PY - 2012/2

Y1 - 2012/2

N2 - Thiopurine drugs have been widely used in the treatment of inflammatory bowel disease. However, their use is limited by adverse effect that can lead to cessation of therapy. We report 2 cases of thiopurine-induced acute pancreatitis in patients with inflammatory bowel disease. Both patients complained of abdominal pain, showed elevated pancreatic enzymes, and swollen pancreases on computed tomography. The patients' signs and symptoms resolved uneventfully after withdrawal of the thiopurine drugs. Although the mechanism of thiopurine-induced pancreatitis remains unclear, close monitoring and early recognition of acute pancreatitis is important in the management of new thiopurine users.

AB - Thiopurine drugs have been widely used in the treatment of inflammatory bowel disease. However, their use is limited by adverse effect that can lead to cessation of therapy. We report 2 cases of thiopurine-induced acute pancreatitis in patients with inflammatory bowel disease. Both patients complained of abdominal pain, showed elevated pancreatic enzymes, and swollen pancreases on computed tomography. The patients' signs and symptoms resolved uneventfully after withdrawal of the thiopurine drugs. Although the mechanism of thiopurine-induced pancreatitis remains unclear, close monitoring and early recognition of acute pancreatitis is important in the management of new thiopurine users.

UR - http://www.scopus.com/inward/record.url?scp=84861503524&partnerID=8YFLogxK

M3 - 学術論文

C2 - 22306545

AN - SCOPUS:84861503524

SN - 0446-6586

VL - 109

SP - 224

EP - 230

JO - Journal of Japanese Society of Gastroenterology

JF - Journal of Japanese Society of Gastroenterology

IS - 2

ER -

Two cases of thiopurine-induced acute pancreatitis in inflammatory bowel disease

Abstract

ASJC Scopus subject areas

Fingerprint

Cite this