Transferrin predicts outcome in patients who underwent liver resection for colorectal liver metastases

Kenei Furukawa; Shinji Onda; Tomohiko Taniai; Ryoga Hamura; Tomotaka Kumamoto; Yoshihiro Shirai; Jungo Yasuda; Koichiro Haruki; Hironori Shiozaki; Takeshi Gocho; Toru Ikegami

doi:10.1093/jjco/hyab096

Transferrin predicts outcome in patients who underwent liver resection for colorectal liver metastases

Kenei Furukawa^*, Shinji Onda, Tomohiko Taniai, Ryoga Hamura, Tomotaka Kumamoto, Yoshihiro Shirai, Jungo Yasuda, Koichiro Haruki, Hironori Shiozaki, Takeshi Gocho, Toru Ikegami

^*Corresponding author for this work

Department of Surgery & Science

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Introduction: The aim of this study is to investigate the relationship between preoperative serum transferrin level and long-term outcomes in patients with colorectal liver metastases after hepatic resection. Methods: We retrospectively investigated 72 patients who underwent hepatic resection for colorectal liver metastases and explored the relationship between serum transferrin level and long-term outcomes. Results: In multivariate analysis, H3 (odds ratio 3.43, 95% confidence interval 1.11-10.89 and P = 0.03) was an independent and significant predictor of the disease-free survival, and a transferrin level ≥ 190 mg/dl (odds ratio 0.20, 95% confidence interval 0.05-0.79 and P = 0.02) and the time to recurrence after hepatectomy <1 year (odds ratio 11.30, 95% confidence interval 2.63-48.59 and P < 0.01) were independent and significant predictors of the overall survival. Conclusions: The serum transferrin level is a useful predictor of poor overall survival in patients with colorectal liver metastases after hepatic reaction.

Original language	English
Pages (from-to)	1400-1406
Number of pages	7
Journal	Japanese Journal of Clinical Oncology
Volume	51
Issue number	9
DOIs	https://doi.org/10.1093/jjco/hyab096
State	Published - 2021/09/01

Keywords

colorectal liver metastases
liver resection
prognosis
transferrin

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Transferrin predicts outcome in patients who underwent liver resection for colorectal liver metastases",

abstract = "Introduction: The aim of this study is to investigate the relationship between preoperative serum transferrin level and long-term outcomes in patients with colorectal liver metastases after hepatic resection. Methods: We retrospectively investigated 72 patients who underwent hepatic resection for colorectal liver metastases and explored the relationship between serum transferrin level and long-term outcomes. Results: In multivariate analysis, H3 (odds ratio 3.43, 95% confidence interval 1.11-10.89 and P = 0.03) was an independent and significant predictor of the disease-free survival, and a transferrin level ≥ 190 mg/dl (odds ratio 0.20, 95% confidence interval 0.05-0.79 and P = 0.02) and the time to recurrence after hepatectomy <1 year (odds ratio 11.30, 95% confidence interval 2.63-48.59 and P < 0.01) were independent and significant predictors of the overall survival. Conclusions: The serum transferrin level is a useful predictor of poor overall survival in patients with colorectal liver metastases after hepatic reaction.",

keywords = "colorectal liver metastases, liver resection, prognosis, transferrin",

author = "Kenei Furukawa and Shinji Onda and Tomohiko Taniai and Ryoga Hamura and Tomotaka Kumamoto and Yoshihiro Shirai and Jungo Yasuda and Koichiro Haruki and Hironori Shiozaki and Takeshi Gocho and Toru Ikegami",

year = "2021",

month = sep,

day = "1",

doi = "10.1093/jjco/hyab096",

language = "英語",

volume = "51",

pages = "1400--1406",

journal = "Japanese Journal of Clinical Oncology",

issn = "0368-2811",

publisher = "Oxford University Press",

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}

TY - JOUR

T1 - Transferrin predicts outcome in patients who underwent liver resection for colorectal liver metastases

AU - Furukawa, Kenei

AU - Onda, Shinji

AU - Taniai, Tomohiko

AU - Hamura, Ryoga

AU - Kumamoto, Tomotaka

AU - Shirai, Yoshihiro

AU - Yasuda, Jungo

AU - Haruki, Koichiro

AU - Shiozaki, Hironori

AU - Gocho, Takeshi

AU - Ikegami, Toru

PY - 2021/9/1

Y1 - 2021/9/1

N2 - Introduction: The aim of this study is to investigate the relationship between preoperative serum transferrin level and long-term outcomes in patients with colorectal liver metastases after hepatic resection. Methods: We retrospectively investigated 72 patients who underwent hepatic resection for colorectal liver metastases and explored the relationship between serum transferrin level and long-term outcomes. Results: In multivariate analysis, H3 (odds ratio 3.43, 95% confidence interval 1.11-10.89 and P = 0.03) was an independent and significant predictor of the disease-free survival, and a transferrin level ≥ 190 mg/dl (odds ratio 0.20, 95% confidence interval 0.05-0.79 and P = 0.02) and the time to recurrence after hepatectomy <1 year (odds ratio 11.30, 95% confidence interval 2.63-48.59 and P < 0.01) were independent and significant predictors of the overall survival. Conclusions: The serum transferrin level is a useful predictor of poor overall survival in patients with colorectal liver metastases after hepatic reaction.

AB - Introduction: The aim of this study is to investigate the relationship between preoperative serum transferrin level and long-term outcomes in patients with colorectal liver metastases after hepatic resection. Methods: We retrospectively investigated 72 patients who underwent hepatic resection for colorectal liver metastases and explored the relationship between serum transferrin level and long-term outcomes. Results: In multivariate analysis, H3 (odds ratio 3.43, 95% confidence interval 1.11-10.89 and P = 0.03) was an independent and significant predictor of the disease-free survival, and a transferrin level ≥ 190 mg/dl (odds ratio 0.20, 95% confidence interval 0.05-0.79 and P = 0.02) and the time to recurrence after hepatectomy <1 year (odds ratio 11.30, 95% confidence interval 2.63-48.59 and P < 0.01) were independent and significant predictors of the overall survival. Conclusions: The serum transferrin level is a useful predictor of poor overall survival in patients with colorectal liver metastases after hepatic reaction.

KW - colorectal liver metastases

KW - liver resection

KW - prognosis

KW - transferrin

UR - http://www.scopus.com/inward/record.url?scp=85115010050&partnerID=8YFLogxK

U2 - 10.1093/jjco/hyab096

DO - 10.1093/jjco/hyab096

M3 - 学術論文

C2 - 34142132

AN - SCOPUS:85115010050

SN - 0368-2811

VL - 51

SP - 1400

EP - 1406

JO - Japanese Journal of Clinical Oncology

JF - Japanese Journal of Clinical Oncology

IS - 9

ER -

Transferrin predicts outcome in patients who underwent liver resection for colorectal liver metastases

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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