Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

Hung Sia Teh; Pawel Kisielow; Bernadette Scott; Hiroyuki Kishi; Yasushi Uematsu; Horst Blüthmann; Harald Von Boehmer

doi:10.1038/335229a0

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

Hung Sia Teh^*, Pawel Kisielow, Bernadette Scott, Hiroyuki Kishi, Yasushi Uematsu, Horst Blüthmann, Harald Von Boehmer

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

676 Scopus citations

Abstract

T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice expressing α and β T-cell receptor genes isolated from a male-specific, H-2D^b-restricted CD4^-8+ T-cell clone. The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens determines the differentiation of CD4⁺8⁺ thymocytes into either CD4⁺8^- or CD4^-8⁺ mature T cells.

Original language	English
Pages (from-to)	229-233
Number of pages	5
Journal	Nature
Volume	335
Issue number	6187
DOIs	https://doi.org/10.1038/335229a0
State	Published - 1988

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title = "Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells",

abstract = "T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice expressing α and β T-cell receptor genes isolated from a male-specific, H-2Db-restricted CD4-8+ T-cell clone. The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens determines the differentiation of CD4+8+ thymocytes into either CD4+8- or CD4-8+ mature T cells.",

author = "Teh, {Hung Sia} and Pawel Kisielow and Bernadette Scott and Hiroyuki Kishi and Yasushi Uematsu and Horst Bl{\"u}thmann and {Von Boehmer}, Harald",

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T1 - Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

AU - Teh, Hung Sia

AU - Kisielow, Pawel

AU - Scott, Bernadette

AU - Kishi, Hiroyuki

AU - Uematsu, Yasushi

AU - Blüthmann, Horst

AU - Von Boehmer, Harald

PY - 1988

Y1 - 1988

N2 - T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice expressing α and β T-cell receptor genes isolated from a male-specific, H-2Db-restricted CD4-8+ T-cell clone. The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens determines the differentiation of CD4+8+ thymocytes into either CD4+8- or CD4-8+ mature T cells.

AB - T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice expressing α and β T-cell receptor genes isolated from a male-specific, H-2Db-restricted CD4-8+ T-cell clone. The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens determines the differentiation of CD4+8+ thymocytes into either CD4+8- or CD4-8+ mature T cells.

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DO - 10.1038/335229a0

M3 - 学術論文

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AN - SCOPUS:0023813094

SN - 0028-0836

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JO - Nature

JF - Nature

IS - 6187

ER -

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

Abstract

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