The roles of natural triterpenoid saponins against Alzheimer's disease

Jie Chun Zhou, Hui Lin Li, Yu Zhou, Xi Tao Li, Zhi You Yang, Chihiro Tohda, Katsuko Komatsu, Xiu Hong Piao*, Yue Wei Ge*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

The aging of the world population and increasing stress levels in life are the major cause of the increased incidence of neurological disorders. Alzheimer's disease (AD) creates a huge burden on the lives and health of individuals and has become a big concern for society. Triterpenoid saponins (TS), representative natural product components, have a wide range of pharmacological bioactivities such as anti-inflammation, antioxidation, antiapoptosis, hormone-like, and gut microbiota regulation. Notably, some natural TS exhibited promising neuroprotective activity that can intervene in AD progress, especially in the early stage. Recently, studies have indicated that TS play a pronounced positive role in the prevention and treatment of AD. This review discusses the recent research on the neuroprotection of TS and proceeds to detail the action mechanisms of TS against AD, hoping to provide a reference for drug development for anti-AD.

Original languageEnglish
Pages (from-to)5017-5040
Number of pages24
JournalPhytotherapy Research
Volume37
Issue number11
DOIs
StatePublished - 2023/11

Keywords

  • Alzheimer's disease
  • action mechanism
  • neuroprotection
  • triterpenoid saponins

ASJC Scopus subject areas

  • Pharmacology

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