Abstract
Choto-san is a Kampo medicines that has been used clinically for the treatment of dementia. We measured the mRNA expressions of some factors related to Alzheimer's disease in a dementia model rat brain. The expressions of β-amyloid precursor protein, γ-secretase, α7 nicotinic acetylcholine receptor, neprilysin, and insulin degrading enzyme (IDE) were significantly increased on day 4 after permanent occlusion of the bilateral common carotid arteries (2VO). Choto-san inhibited the enhancement of IDE expression caused by 2VO, although it failed to show any effects on the expressions of the other molecules. These results suggest that Choto-san may produce a state in which it is not necessary to induce IDE expression to demonstrate the anti-dementia effects.
| Original language | English |
|---|---|
| Pages (from-to) | 744-746 |
| Number of pages | 3 |
| Journal | Biological and Pharmaceutical Bulletin |
| Volume | 28 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2005/04 |
Keywords
- Alzheimer's disease
- Choto-san
- Neprilysin
- mRNA expression
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science