The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia

Tsutomu Takahashi, Michio Suzuki*, Masahiko Tsunoda, Nobuhisa Maeno, Yasuhiro Kawasaki, Shi Yu Zhou, Hirofumi Hagino, Lisha Niu, Hiroshi Tsuneki, Soushi Kobayashi, Toshiyasu Sasaoka, Hikaru Seto, Masayoshi Kurachi, Norio Ozaki

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

The Disrupted-in-Schizophrenia-1 (DISC1) polymorphism is a strong candidate for a schizophrenia-susceptibility gene as it is widely expressed in cortical and limbic regions, but the effect of its genotype variation on brain morphology in schizophrenia is not well known. This study examined the association between the DISC1 Ser704Cys polymorphism and volumetric measurements for a broad range of fronto-parietal, temporal, and limbic-paralimbic regions using magnetic resonance imaging in a Japanese sample of 33 schizophrenia patients and 29 healthy comparison subjects. The Cys carriers had significantly larger volumes of the medial superior frontal gyrus and short insular cortex than the Ser homozygotes only for healthy comparison subjects. The Cys carriers tended to have a smaller supramarginal gyrus than the Ser homozygotes in schizophrenia patients, but not in healthy comparison subjects. The right medial superior frontal gyrus volume was significantly correlated with daily dosage of antipsychotic medication in Ser homozygote schizophrenia patients. These different genotype effects of the DISC1 Ser704Cys polymorphism on the brain morphology in schizophrenia patients and healthy comparison subjects suggest that variation in the DISC1 gene might be, at least partly, involved in the neurobiology of schizophrenia. Our findings also suggest that the DISC1 genotype variation might have some relevance to the medication effect on brain morphology in schizophrenia.

Original languageEnglish
Pages (from-to)128-135
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume172
Issue number2
DOIs
StatePublished - 2009/05/15

Keywords

  • Antipsychotic medication
  • DISC1
  • Insular cortex
  • Magnetic resonance imaging
  • Prefrontal cortex
  • Supramarginal gyrus

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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