TY - JOUR
T1 - The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structures
AU - Takahashi, Tsutomu
AU - Suzuki, Michio
AU - Tsunoda, Masahiko
AU - Kawamura, Yukiko
AU - Takahashi, Nagahide
AU - Maeno, Nobuhisa
AU - Kawasaki, Yasuhiro
AU - Zhou, Shi Yu
AU - Hagino, Hirofumi
AU - Niu, Lisha
AU - Tsuneki, Hiroshi
AU - Kobayashi, Soushi
AU - Sasaoka, Toshiyasu
AU - Seto, Hikaru
AU - Kurachi, Masayoshi
AU - Ozaki, Norio
PY - 2008/7/1
Y1 - 2008/7/1
N2 - Abnormal neurodevelopment in midline structures such as the adhesio interthalamica (AI), as well as in the medial temporal lobe structures has been implicated in schizophrenia, while its genetic mechanism is unknown. This magnetic resonance imaging study investigated the effect of the genotypic combination of the dopamine D3 receptor (DRD3) Ser9Gly and brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms on the AI length and volumetric measures of the medial temporal lobe structures (amygdala, hippocampus, and parahippocampal gyrus) in 33 schizophrenia patients and 29 healthy controls. The subjects with a combination of the Ser/Ser genotype of DRD3 and Met-containing genotypes of BDNF (high-risk combination) had a shorter AI than those without it in the healthy controls, but not in the schizophrenia patients. The subjects carrying the high-risk combination had a smaller posterior hippocampus than those without it for both diagnostic groups. These genotypic combination effects on brain morphology were not explained by the independent effect of each polymorphism. These findings suggest the effect of gene-gene interaction between the DRD3 and BDNF variations on brain morphology in midline and medial temporal lobe structures, but do not support its specific role in the pathogenesis of schizophrenia.
AB - Abnormal neurodevelopment in midline structures such as the adhesio interthalamica (AI), as well as in the medial temporal lobe structures has been implicated in schizophrenia, while its genetic mechanism is unknown. This magnetic resonance imaging study investigated the effect of the genotypic combination of the dopamine D3 receptor (DRD3) Ser9Gly and brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms on the AI length and volumetric measures of the medial temporal lobe structures (amygdala, hippocampus, and parahippocampal gyrus) in 33 schizophrenia patients and 29 healthy controls. The subjects with a combination of the Ser/Ser genotype of DRD3 and Met-containing genotypes of BDNF (high-risk combination) had a shorter AI than those without it in the healthy controls, but not in the schizophrenia patients. The subjects carrying the high-risk combination had a smaller posterior hippocampus than those without it for both diagnostic groups. These genotypic combination effects on brain morphology were not explained by the independent effect of each polymorphism. These findings suggest the effect of gene-gene interaction between the DRD3 and BDNF variations on brain morphology in midline and medial temporal lobe structures, but do not support its specific role in the pathogenesis of schizophrenia.
KW - Adhesio interthalamica
KW - Brain-derived neurotrophic factor
KW - Dopamine D3 receptor
KW - Gene-gene interaction
KW - Magnetic resonance imaging
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=49849089355&partnerID=8YFLogxK
U2 - 10.1016/j.pnpbp.2008.03.014
DO - 10.1016/j.pnpbp.2008.03.014
M3 - 学術論文
C2 - 18472202
AN - SCOPUS:49849089355
SN - 0278-5846
VL - 32
SP - 1236
EP - 1242
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
IS - 5
ER -