Tandem Migration-Carboalkoxylation of o-Isocyanophenyl Acetals Leading to Benzoxazoles

Takashi Okitsu; Kenta Nagase; Nobuhiko Nishio; Akimori Wada

doi:10.1021/ol203175a

Tandem Migration-Carboalkoxylation of o-Isocyanophenyl Acetals Leading to Benzoxazoles

Takashi Okitsu, Kenta Nagase, Nobuhiko Nishio, Akimori Wada^*

^*Corresponding author for this work

Synthetic and Biomolecular Organic Chemistry

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

An efficient approach to benzoxazoles via tandem migration - carboalkoxylation of o-isocyanophenyl acetals has been developed. Both a Lewis acid and base are essential for this reaction, and the BF ₃· OEt ₂/2,4,6-collidine combination is the best choice for cooperative transformation.

Original language	English
Pages (from-to)	708-711
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	3
DOIs	https://doi.org/10.1021/ol203175a
State	Published - 2012/02/03

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol203175a

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title = "Tandem Migration-Carboalkoxylation of o-Isocyanophenyl Acetals Leading to Benzoxazoles",

abstract = "An efficient approach to benzoxazoles via tandem migration - carboalkoxylation of o-isocyanophenyl acetals has been developed. Both a Lewis acid and base are essential for this reaction, and the BF 3· OEt 2/2,4,6-collidine combination is the best choice for cooperative transformation.",

author = "Takashi Okitsu and Kenta Nagase and Nobuhiko Nishio and Akimori Wada",

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AU - Okitsu, Takashi

AU - Nagase, Kenta

AU - Nishio, Nobuhiko

AU - Wada, Akimori

PY - 2012/2/3

Y1 - 2012/2/3

N2 - An efficient approach to benzoxazoles via tandem migration - carboalkoxylation of o-isocyanophenyl acetals has been developed. Both a Lewis acid and base are essential for this reaction, and the BF 3· OEt 2/2,4,6-collidine combination is the best choice for cooperative transformation.

AB - An efficient approach to benzoxazoles via tandem migration - carboalkoxylation of o-isocyanophenyl acetals has been developed. Both a Lewis acid and base are essential for this reaction, and the BF 3· OEt 2/2,4,6-collidine combination is the best choice for cooperative transformation.

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JO - Organic Letters

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Tandem Migration-Carboalkoxylation of o-Isocyanophenyl Acetals Leading to Benzoxazoles

Abstract

ASJC Scopus subject areas

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