Synthesis of two naturally occurring 3-methyl-2,5-dihydro-1-benzoxepin carboxylic acids

Seiji Yamaguchi; Nao Tsuchida; Masahiro Miyazawa; Yoshiro Hirai

doi:10.1021/jo050550l

Synthesis of two naturally occurring 3-methyl-2,5-dihydro-1-benzoxepin carboxylic acids

Seiji Yamaguchi^*, Nao Tsuchida, Masahiro Miyazawa, Yoshiro Hirai

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Two naturally occurring 3-methyl-2,5-dihydro-1-benzoxepin carboxylic acids, 6-hydroxy-3-methyl-8-(phenylethyl)-2,5-dihydro-1-benzoxepin-9-carboxylic acid (radulanin E) (1) and 9-hydroxy-3-methyl-2,5-dihydro-1-benzoxepin-7-carboxylic acid (2), were synthesized using Stille coupling followed by Mitsunobu cyclization.

Original language	English
Pages (from-to)	7505-7511
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	70
Issue number	19
DOIs	https://doi.org/10.1021/jo050550l
State	Published - 2005/09/16

ASJC Scopus subject areas

Organic Chemistry

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@article{afc9dbc404574e3db26963dbd7f7b014,

title = "Synthesis of two naturally occurring 3-methyl-2,5-dihydro-1-benzoxepin carboxylic acids",

abstract = "Two naturally occurring 3-methyl-2,5-dihydro-1-benzoxepin carboxylic acids, 6-hydroxy-3-methyl-8-(phenylethyl)-2,5-dihydro-1-benzoxepin-9-carboxylic acid (radulanin E) (1) and 9-hydroxy-3-methyl-2,5-dihydro-1-benzoxepin-7-carboxylic acid (2), were synthesized using Stille coupling followed by Mitsunobu cyclization.",

author = "Seiji Yamaguchi and Nao Tsuchida and Masahiro Miyazawa and Yoshiro Hirai",

year = "2005",

month = sep,

day = "16",

doi = "10.1021/jo050550l",

language = "英語",

volume = "70",

pages = "7505--7511",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "19",

}

TY - JOUR

T1 - Synthesis of two naturally occurring 3-methyl-2,5-dihydro-1-benzoxepin carboxylic acids

AU - Yamaguchi, Seiji

AU - Tsuchida, Nao

AU - Miyazawa, Masahiro

AU - Hirai, Yoshiro

PY - 2005/9/16

Y1 - 2005/9/16

N2 - Two naturally occurring 3-methyl-2,5-dihydro-1-benzoxepin carboxylic acids, 6-hydroxy-3-methyl-8-(phenylethyl)-2,5-dihydro-1-benzoxepin-9-carboxylic acid (radulanin E) (1) and 9-hydroxy-3-methyl-2,5-dihydro-1-benzoxepin-7-carboxylic acid (2), were synthesized using Stille coupling followed by Mitsunobu cyclization.

AB - Two naturally occurring 3-methyl-2,5-dihydro-1-benzoxepin carboxylic acids, 6-hydroxy-3-methyl-8-(phenylethyl)-2,5-dihydro-1-benzoxepin-9-carboxylic acid (radulanin E) (1) and 9-hydroxy-3-methyl-2,5-dihydro-1-benzoxepin-7-carboxylic acid (2), were synthesized using Stille coupling followed by Mitsunobu cyclization.

UR - http://www.scopus.com/inward/record.url?scp=24944532134&partnerID=8YFLogxK

U2 - 10.1021/jo050550l

DO - 10.1021/jo050550l

M3 - 学術論文

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AN - SCOPUS:24944532134

SN - 0022-3263

VL - 70

SP - 7505

EP - 7511

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 19

ER -

Synthesis of two naturally occurring 3-methyl-2,5-dihydro-1-benzoxepin carboxylic acids

Abstract

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