Synthesis of the C8-C15 segment of (+)-discodermolide

Masahiro Miyazawa, Satoshi Oonuma, Kimiyuki Maruyama, Masaaki Miyashita*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Succeeding to the preceding paper, stereoselective synthesis of the C8-C15 segment of (+)-discodermolide (1), the marine natural product having the potent immunosuppressive activity, is described in which the contiguous asymmetric centers at C11 and C12 positions were stereospecifically constructed via the methylation of an epoxy alcohol with lithium dimethylcuprate.

Original languageEnglish
Pages (from-to)1193-1194
Number of pages2
JournalChemistry Letters
Issue number12
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • General Chemistry

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