Synthesis of tetra‐aza macrocycles with remarkably high efficiency

Takenori Tomohiro; Kouichi Uoto; Takehiko Shimura; Hiroaki Okuno

doi:10.1002/jhet.5570250540

Synthesis of tetra‐aza macrocycles with remarkably high efficiency

Takenori Tomohiro^*, Kouichi Uoto, Takehiko Shimura, Hiroaki Okuno

^*Corresponding author for this work

Biorecognition Chemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Tetra‐aza macrocycles with 28‐ to 44‐membered rings can be readily synthesized by reaction of dibromide and ditosyldiamide without use of a high dilution method. The reaction proceeded very smoothly with a 10 mM concentration in DMF, and gave the macrocycles in excellent yields (60–80%). Favorable effects of cesium ion on the cyclization have been observed.

Original language	English
Pages (from-to)	1463-1465
Number of pages	3
Journal	Journal of Heterocyclic Chemistry
Volume	25
Issue number	5
DOIs	https://doi.org/10.1002/jhet.5570250540
State	Published - 1988

ASJC Scopus subject areas

Organic Chemistry

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@article{13db578720bf4a328b25eaacab90b876,

title = "Synthesis of tetra‐aza macrocycles with remarkably high efficiency",

abstract = "Tetra‐aza macrocycles with 28‐ to 44‐membered rings can be readily synthesized by reaction of dibromide and ditosyldiamide without use of a high dilution method. The reaction proceeded very smoothly with a 10 mM concentration in DMF, and gave the macrocycles in excellent yields (60–80%). Favorable effects of cesium ion on the cyclization have been observed.",

author = "Takenori Tomohiro and Kouichi Uoto and Takehiko Shimura and Hiroaki Okuno",

year = "1988",

doi = "10.1002/jhet.5570250540",

language = "英語",

volume = "25",

pages = "1463--1465",

journal = "Journal of Heterocyclic Chemistry",

issn = "0022-152X",

publisher = "John Wiley and Sons Inc.",

number = "5",

}

TY - JOUR

T1 - Synthesis of tetra‐aza macrocycles with remarkably high efficiency

AU - Tomohiro, Takenori

AU - Uoto, Kouichi

AU - Shimura, Takehiko

AU - Okuno, Hiroaki

PY - 1988

Y1 - 1988

N2 - Tetra‐aza macrocycles with 28‐ to 44‐membered rings can be readily synthesized by reaction of dibromide and ditosyldiamide without use of a high dilution method. The reaction proceeded very smoothly with a 10 mM concentration in DMF, and gave the macrocycles in excellent yields (60–80%). Favorable effects of cesium ion on the cyclization have been observed.

AB - Tetra‐aza macrocycles with 28‐ to 44‐membered rings can be readily synthesized by reaction of dibromide and ditosyldiamide without use of a high dilution method. The reaction proceeded very smoothly with a 10 mM concentration in DMF, and gave the macrocycles in excellent yields (60–80%). Favorable effects of cesium ion on the cyclization have been observed.

UR - http://www.scopus.com/inward/record.url?scp=84986528057&partnerID=8YFLogxK

U2 - 10.1002/jhet.5570250540

DO - 10.1002/jhet.5570250540

M3 - 学術論文

AN - SCOPUS:84986528057

SN - 0022-152X

VL - 25

SP - 1463

EP - 1465

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

IS - 5

ER -

Synthesis of tetra‐aza macrocycles with remarkably high efficiency

Abstract

ASJC Scopus subject areas

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