Synthesis of macrosphelides with a thiazole side chain: New antitumor candidates having apoptosis-inducing property

Yuji Matsuya; Takanori Kawaguchi; Kentaro Ishihara; Kanwal Ahmed; Qing Li Zhao; Takashi Kondo; Hideo Nemoto

doi:10.1021/ol061922v

Synthesis of macrosphelides with a thiazole side chain: New antitumor candidates having apoptosis-inducing property

Yuji Matsuya, Takanori Kawaguchi, Kentaro Ishihara, Kanwal Ahmed, Qing Li Zhao, Takashi Kondo, Hideo Nemoto^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Hybrid compounds of macrosphelides and epothilones, both of which are natural macrolides having a 16-membered skeleton, were designed and synthesized using a ring-closing metathesis (RCM) strategy. Some of these hybrids were found to exhibit notable apoptosis-inducing activity against human lymphoma cells with higher potency than parent natural macrosphelides, and to be a promising lead compound for development of a new antitumor agent.

Original language	English
Pages (from-to)	4609-4612
Number of pages	4
Journal	Organic Letters
Volume	8
Issue number	20
DOIs	https://doi.org/10.1021/ol061922v
State	Published - 2006/09/28

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol061922v

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title = "Synthesis of macrosphelides with a thiazole side chain: New antitumor candidates having apoptosis-inducing property",

abstract = "Hybrid compounds of macrosphelides and epothilones, both of which are natural macrolides having a 16-membered skeleton, were designed and synthesized using a ring-closing metathesis (RCM) strategy. Some of these hybrids were found to exhibit notable apoptosis-inducing activity against human lymphoma cells with higher potency than parent natural macrosphelides, and to be a promising lead compound for development of a new antitumor agent.",

author = "Yuji Matsuya and Takanori Kawaguchi and Kentaro Ishihara and Kanwal Ahmed and Zhao, {Qing Li} and Takashi Kondo and Hideo Nemoto",

year = "2006",

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doi = "10.1021/ol061922v",

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T1 - Synthesis of macrosphelides with a thiazole side chain

T2 - New antitumor candidates having apoptosis-inducing property

AU - Matsuya, Yuji

AU - Kawaguchi, Takanori

AU - Ishihara, Kentaro

AU - Ahmed, Kanwal

AU - Zhao, Qing Li

AU - Kondo, Takashi

AU - Nemoto, Hideo

PY - 2006/9/28

Y1 - 2006/9/28

N2 - Hybrid compounds of macrosphelides and epothilones, both of which are natural macrolides having a 16-membered skeleton, were designed and synthesized using a ring-closing metathesis (RCM) strategy. Some of these hybrids were found to exhibit notable apoptosis-inducing activity against human lymphoma cells with higher potency than parent natural macrosphelides, and to be a promising lead compound for development of a new antitumor agent.

AB - Hybrid compounds of macrosphelides and epothilones, both of which are natural macrolides having a 16-membered skeleton, were designed and synthesized using a ring-closing metathesis (RCM) strategy. Some of these hybrids were found to exhibit notable apoptosis-inducing activity against human lymphoma cells with higher potency than parent natural macrosphelides, and to be a promising lead compound for development of a new antitumor agent.

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U2 - 10.1021/ol061922v

DO - 10.1021/ol061922v

M3 - 学術論文

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SN - 1523-7060

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JO - Organic Letters

JF - Organic Letters

IS - 20

ER -

Synthesis of macrosphelides with a thiazole side chain: New antitumor candidates having apoptosis-inducing property

Abstract

ASJC Scopus subject areas

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