Successful treatment of histiocytic sarcoma with cladribine and high-dose cytosine arabinoside in a child

Haruko Iwabuchi; Hiroyuki Kawashima; Hajime Umezu; Takayuki Takachi; Masaru Imamura; Akihiko Saitoh; Akira Ogose; Chihaya Imai

doi:10.1007/s12185-017-2202-8

Successful treatment of histiocytic sarcoma with cladribine and high-dose cytosine arabinoside in a child

Haruko Iwabuchi, Hiroyuki Kawashima, Hajime Umezu, Takayuki Takachi, Masaru Imamura, Akihiko Saitoh, Akira Ogose, Chihaya Imai^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Histiocytic sarcoma, a rare hematopoietic neoplasm with evidence of histiocytic differentiation, is often refractory to conventional chemotherapy and radiotherapy, and its prognosis is generally dismal. The optimal management of this malignancy has not been established. We report a case of 8-year-old girl with histiocytic sarcoma involving the left femur. The tumor rapidly responded to a combination of cladribine and high-dose cytosine arabinoside, an aggressive salvage regimen for refractory Langerhans cell histiocytosis, and became impalpable during the first cycle. The patient has remained in complete remission more than 7 years from diagnosis.

Original language	English
Pages (from-to)	299-303
Number of pages	5
Journal	International Journal of Hematology
Volume	106
Issue number	2
DOIs	https://doi.org/10.1007/s12185-017-2202-8
State	Published - 2017/08/01

Keywords

Cladribine
Cytosine arabinoside
Histiocytic sarcoma

ASJC Scopus subject areas

Hematology

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10.1007/s12185-017-2202-8

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title = "Successful treatment of histiocytic sarcoma with cladribine and high-dose cytosine arabinoside in a child",

abstract = "Histiocytic sarcoma, a rare hematopoietic neoplasm with evidence of histiocytic differentiation, is often refractory to conventional chemotherapy and radiotherapy, and its prognosis is generally dismal. The optimal management of this malignancy has not been established. We report a case of 8-year-old girl with histiocytic sarcoma involving the left femur. The tumor rapidly responded to a combination of cladribine and high-dose cytosine arabinoside, an aggressive salvage regimen for refractory Langerhans cell histiocytosis, and became impalpable during the first cycle. The patient has remained in complete remission more than 7 years from diagnosis.",

keywords = "Cladribine, Cytosine arabinoside, Histiocytic sarcoma",

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doi = "10.1007/s12185-017-2202-8",

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AU - Iwabuchi, Haruko

AU - Kawashima, Hiroyuki

AU - Umezu, Hajime

AU - Takachi, Takayuki

AU - Imamura, Masaru

AU - Saitoh, Akihiko

AU - Ogose, Akira

AU - Imai, Chihaya

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Histiocytic sarcoma, a rare hematopoietic neoplasm with evidence of histiocytic differentiation, is often refractory to conventional chemotherapy and radiotherapy, and its prognosis is generally dismal. The optimal management of this malignancy has not been established. We report a case of 8-year-old girl with histiocytic sarcoma involving the left femur. The tumor rapidly responded to a combination of cladribine and high-dose cytosine arabinoside, an aggressive salvage regimen for refractory Langerhans cell histiocytosis, and became impalpable during the first cycle. The patient has remained in complete remission more than 7 years from diagnosis.

AB - Histiocytic sarcoma, a rare hematopoietic neoplasm with evidence of histiocytic differentiation, is often refractory to conventional chemotherapy and radiotherapy, and its prognosis is generally dismal. The optimal management of this malignancy has not been established. We report a case of 8-year-old girl with histiocytic sarcoma involving the left femur. The tumor rapidly responded to a combination of cladribine and high-dose cytosine arabinoside, an aggressive salvage regimen for refractory Langerhans cell histiocytosis, and became impalpable during the first cycle. The patient has remained in complete remission more than 7 years from diagnosis.

KW - Cladribine

KW - Cytosine arabinoside

KW - Histiocytic sarcoma

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DO - 10.1007/s12185-017-2202-8

M3 - 学術論文

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AN - SCOPUS:85014047487

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Successful treatment of histiocytic sarcoma with cladribine and high-dose cytosine arabinoside in a child

Abstract

Keywords

ASJC Scopus subject areas

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