Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features

Daiken Satake; Manabu Natsumeda; Kaishi Satomi; Mari Tada; Taro Sato; Noritaka Okubo; Keita Kawabe; Haruhiko Takahashi; Yoshihiro Tsukamoto; Masayasu Okada; Masakazu Sano; Haruko Iwabuchi; Nao Shibata; Masaru Imamura; Chihaya Imai; Hirokazu Takami; Koichi Ichimura; Ryo Nishikawa; Hajime Umezu; Akiyoshi Kakita; Makoto Oishi

doi:10.3390/curroncol31040138

Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features

Daiken Satake, Manabu Natsumeda^*, Kaishi Satomi, Mari Tada, Taro Sato, Noritaka Okubo, Keita Kawabe, Haruhiko Takahashi, Yoshihiro Tsukamoto, Masayasu Okada, Masakazu Sano, Haruko Iwabuchi, Nao Shibata, Masaru Imamura, Chihaya Imai, Hirokazu Takami, Koichi Ichimura, Ryo Nishikawa, Hajime Umezu, Akiyoshi KakitaMakoto Oishi

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Molecular analysis of the growing teratoma syndrome has not been extensively studied. Here, we report a 14-year-old boy with a growing mass during treatment for a mixed germ cell tumor of the pineal region. Tumor markers were negative; thus, growing teratoma syndrome was suspected. A radical resection via the occipital transtentorial approach was performed, and histopathological examination revealed a teratoma with malignant features. Methylation classifier analysis confirmed the diagnosis of teratoma, and DMRT1 loss and 12p gain were identified by copy number variation analysis, potentially elucidating the cause of growth and malignant transformation of the teratoma. The patient remains in remission after intense chemoradiation treatment as a high-risk germ cell tumor.

Original language	English
Pages (from-to)	1831-1838
Number of pages	8
Journal	Current Oncology
Volume	31
Issue number	4
DOIs	https://doi.org/10.3390/curroncol31040138
State	Published - 2024/04

Keywords

copy number variation analysis
growing teratoma syndrome
methylation classifier
multimodal treatment

ASJC Scopus subject areas

Oncology

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10.3390/curroncol31040138

Cite this

Satake, D., Natsumeda, M., Satomi, K., Tada, M., Sato, T., Okubo, N., Kawabe, K., Takahashi, H., Tsukamoto, Y., Okada, M., Sano, M., Iwabuchi, H., Shibata, N., Imamura, M., Imai, C., Takami, H., Ichimura, K., Nishikawa, R., Umezu, H., ... Oishi, M. (2024). Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features. Current Oncology, 31(4), 1831-1838. https://doi.org/10.3390/curroncol31040138

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title = "Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features",

abstract = "Molecular analysis of the growing teratoma syndrome has not been extensively studied. Here, we report a 14-year-old boy with a growing mass during treatment for a mixed germ cell tumor of the pineal region. Tumor markers were negative; thus, growing teratoma syndrome was suspected. A radical resection via the occipital transtentorial approach was performed, and histopathological examination revealed a teratoma with malignant features. Methylation classifier analysis confirmed the diagnosis of teratoma, and DMRT1 loss and 12p gain were identified by copy number variation analysis, potentially elucidating the cause of growth and malignant transformation of the teratoma. The patient remains in remission after intense chemoradiation treatment as a high-risk germ cell tumor.",

keywords = "copy number variation analysis, growing teratoma syndrome, methylation classifier, multimodal treatment",

author = "Daiken Satake and Manabu Natsumeda and Kaishi Satomi and Mari Tada and Taro Sato and Noritaka Okubo and Keita Kawabe and Haruhiko Takahashi and Yoshihiro Tsukamoto and Masayasu Okada and Masakazu Sano and Haruko Iwabuchi and Nao Shibata and Masaru Imamura and Chihaya Imai and Hirokazu Takami and Koichi Ichimura and Ryo Nishikawa and Hajime Umezu and Akiyoshi Kakita and Makoto Oishi",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = apr,

doi = "10.3390/curroncol31040138",

language = "英語",

volume = "31",

pages = "1831--1838",

journal = "Current Oncology",

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Satake, D, Natsumeda, M, Satomi, K, Tada, M, Sato, T, Okubo, N, Kawabe, K, Takahashi, H, Tsukamoto, Y, Okada, M, Sano, M, Iwabuchi, H, Shibata, N, Imamura, M, Imai, C, Takami, H, Ichimura, K, Nishikawa, R, Umezu, H, Kakita, A & Oishi, M 2024, 'Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features', Current Oncology, vol. 31, no. 4, pp. 1831-1838. https://doi.org/10.3390/curroncol31040138

TY - JOUR

T1 - Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features

AU - Satake, Daiken

AU - Natsumeda, Manabu

AU - Satomi, Kaishi

AU - Tada, Mari

AU - Sato, Taro

AU - Okubo, Noritaka

AU - Kawabe, Keita

AU - Takahashi, Haruhiko

AU - Tsukamoto, Yoshihiro

AU - Okada, Masayasu

AU - Sano, Masakazu

AU - Iwabuchi, Haruko

AU - Shibata, Nao

AU - Imamura, Masaru

AU - Imai, Chihaya

AU - Takami, Hirokazu

AU - Ichimura, Koichi

AU - Nishikawa, Ryo

AU - Umezu, Hajime

AU - Kakita, Akiyoshi

AU - Oishi, Makoto

PY - 2024/4

Y1 - 2024/4

N2 - Molecular analysis of the growing teratoma syndrome has not been extensively studied. Here, we report a 14-year-old boy with a growing mass during treatment for a mixed germ cell tumor of the pineal region. Tumor markers were negative; thus, growing teratoma syndrome was suspected. A radical resection via the occipital transtentorial approach was performed, and histopathological examination revealed a teratoma with malignant features. Methylation classifier analysis confirmed the diagnosis of teratoma, and DMRT1 loss and 12p gain were identified by copy number variation analysis, potentially elucidating the cause of growth and malignant transformation of the teratoma. The patient remains in remission after intense chemoradiation treatment as a high-risk germ cell tumor.

AB - Molecular analysis of the growing teratoma syndrome has not been extensively studied. Here, we report a 14-year-old boy with a growing mass during treatment for a mixed germ cell tumor of the pineal region. Tumor markers were negative; thus, growing teratoma syndrome was suspected. A radical resection via the occipital transtentorial approach was performed, and histopathological examination revealed a teratoma with malignant features. Methylation classifier analysis confirmed the diagnosis of teratoma, and DMRT1 loss and 12p gain were identified by copy number variation analysis, potentially elucidating the cause of growth and malignant transformation of the teratoma. The patient remains in remission after intense chemoradiation treatment as a high-risk germ cell tumor.

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KW - growing teratoma syndrome

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JO - Current Oncology

JF - Current Oncology

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ER -

Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features

Abstract

Keywords

ASJC Scopus subject areas

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