Successful conversion from thiazide to tolvaptan in a patient with stage D heart failure and chronic kidney disease before heart transplantation

Teruhiko Imamura; Koichiro Kinugawa; Naoko Kato; Shun Minatsuki; Hironori Muraoka; Toshiro Inaba; Hisataka Maki; Taro Shiga; Masaru Hatano; Atsushi Yao; Shunei Kyo; Minoru Ono; Issei Komuro

doi:10.1536/ihj.54.48

Successful conversion from thiazide to tolvaptan in a patient with stage D heart failure and chronic kidney disease before heart transplantation

Teruhiko Imamura, Koichiro Kinugawa^*, Naoko Kato, Shun Minatsuki, Hironori Muraoka, Toshiro Inaba, Hisataka Maki, Taro Shiga, Masaru Hatano, Atsushi Yao, Shunei Kyo, Minoru Ono, Issei Komuro

^*Corresponding author for this work

Internal Medicine （2）

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Chronic kidney disease (CKD) is often complicated with advanced heart failure because of not only renal congestion and decreased renal perfusion but also prolonged use of diuretics at higher doses, which sometimes results in hyponatremia. Preoperative CKD is known to be associated with poor prognosis after heart transplantation (HTx). We experienced a stage D heart failure patient with CKD and hyponatremia who was switched from trichlormethiazide to tolvaptan. His hyponatremia was normalized, and his renal function was improved after conversion to tolvaptan. In patients with stage D heart failure, it may be useful to administer tolvaptan with a concomitant reduction in the dose of diuretics in order to preserve renal function and avoid hyponatremia before HTx.

Original language	English
Pages (from-to)	48-50
Number of pages	3
Journal	International Heart Journal
Volume	54
Issue number	1
DOIs	https://doi.org/10.1536/ihj.54.48
State	Published - 2013/02

Keywords

Diuretics
Hyponatremia
Renal dysfunction

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1536/ihj.54.48

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Imamura, T., Kinugawa, K., Kato, N., Minatsuki, S., Muraoka, H., Inaba, T., Maki, H., Shiga, T., Hatano, M., Yao, A., Kyo, S., Ono, M., & Komuro, I. (2013). Successful conversion from thiazide to tolvaptan in a patient with stage D heart failure and chronic kidney disease before heart transplantation. International Heart Journal, 54(1), 48-50. https://doi.org/10.1536/ihj.54.48

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abstract = "Chronic kidney disease (CKD) is often complicated with advanced heart failure because of not only renal congestion and decreased renal perfusion but also prolonged use of diuretics at higher doses, which sometimes results in hyponatremia. Preoperative CKD is known to be associated with poor prognosis after heart transplantation (HTx). We experienced a stage D heart failure patient with CKD and hyponatremia who was switched from trichlormethiazide to tolvaptan. His hyponatremia was normalized, and his renal function was improved after conversion to tolvaptan. In patients with stage D heart failure, it may be useful to administer tolvaptan with a concomitant reduction in the dose of diuretics in order to preserve renal function and avoid hyponatremia before HTx.",

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author = "Teruhiko Imamura and Koichiro Kinugawa and Naoko Kato and Shun Minatsuki and Hironori Muraoka and Toshiro Inaba and Hisataka Maki and Taro Shiga and Masaru Hatano and Atsushi Yao and Shunei Kyo and Minoru Ono and Issei Komuro",

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Imamura, T , Kinugawa, K, Kato, N, Minatsuki, S, Muraoka, H, Inaba, T, Maki, H, Shiga, T, Hatano, M, Yao, A, Kyo, S, Ono, M & Komuro, I 2013, 'Successful conversion from thiazide to tolvaptan in a patient with stage D heart failure and chronic kidney disease before heart transplantation', International Heart Journal, vol. 54, no. 1, pp. 48-50. https://doi.org/10.1536/ihj.54.48

TY - JOUR

T1 - Successful conversion from thiazide to tolvaptan in a patient with stage D heart failure and chronic kidney disease before heart transplantation

AU - Imamura, Teruhiko

AU - Kinugawa, Koichiro

AU - Kato, Naoko

AU - Minatsuki, Shun

AU - Muraoka, Hironori

AU - Inaba, Toshiro

AU - Maki, Hisataka

AU - Shiga, Taro

AU - Hatano, Masaru

AU - Yao, Atsushi

AU - Kyo, Shunei

AU - Ono, Minoru

AU - Komuro, Issei

PY - 2013/2

Y1 - 2013/2

N2 - Chronic kidney disease (CKD) is often complicated with advanced heart failure because of not only renal congestion and decreased renal perfusion but also prolonged use of diuretics at higher doses, which sometimes results in hyponatremia. Preoperative CKD is known to be associated with poor prognosis after heart transplantation (HTx). We experienced a stage D heart failure patient with CKD and hyponatremia who was switched from trichlormethiazide to tolvaptan. His hyponatremia was normalized, and his renal function was improved after conversion to tolvaptan. In patients with stage D heart failure, it may be useful to administer tolvaptan with a concomitant reduction in the dose of diuretics in order to preserve renal function and avoid hyponatremia before HTx.

AB - Chronic kidney disease (CKD) is often complicated with advanced heart failure because of not only renal congestion and decreased renal perfusion but also prolonged use of diuretics at higher doses, which sometimes results in hyponatremia. Preoperative CKD is known to be associated with poor prognosis after heart transplantation (HTx). We experienced a stage D heart failure patient with CKD and hyponatremia who was switched from trichlormethiazide to tolvaptan. His hyponatremia was normalized, and his renal function was improved after conversion to tolvaptan. In patients with stage D heart failure, it may be useful to administer tolvaptan with a concomitant reduction in the dose of diuretics in order to preserve renal function and avoid hyponatremia before HTx.

KW - Diuretics

KW - Hyponatremia

KW - Renal dysfunction

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Successful conversion from thiazide to tolvaptan in a patient with stage D heart failure and chronic kidney disease before heart transplantation

Abstract

Keywords

ASJC Scopus subject areas

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