Successful control of opioid-refractory cancer pain with methadone in a patient with advanced oral squamous cell carcinoma: A case report

Katsuhisa Sekido; Kei Tomihara; Hideyo Horikawa; Hidetake Tachinami; Nozomu Murakami; Makoto Noguchi

doi:10.1016/S1348-8643(18)30004-1

Successful control of opioid-refractory cancer pain with methadone in a patient with advanced oral squamous cell carcinoma: A case report

Katsuhisa Sekido, Kei Tomihara^*, Hideyo Horikawa, Hidetake Tachinami, Nozomu Murakami, Makoto Noguchi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Methadone, a synthetic opioid agonist, is used for pain that is refractory to other opioids. However, limited data on its ability to control pain in patients with oral cancer are available. In this study, we present a case of recurrent oral cancer, in which pain was poorly controlled with high-dose oxycodone but successfully controlled with methadone. A 36-year-old male patient was referred to our hospital for the treatment of recurrent oral cancer. His pain no longer responded to increased dosages of oxycodone, and thus oxycodone was switched to methadone. Ultimately, his pain was successfully controlled with methadone throughout his end-of-life stage.

Original language	English
Pages (from-to)	78-80
Number of pages	3
Journal	Oral Science International
Volume	15
Issue number	2
DOIs	https://doi.org/10.1016/S1348-8643(18)30004-1
State	Published - 2018/07

Keywords

Cancer pain
Methadone
Opioids
Oral squamous cell carcinoma
Palliative care

ASJC Scopus subject areas

Otorhinolaryngology

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10.1016/S1348-8643(18)30004-1

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title = "Successful control of opioid-refractory cancer pain with methadone in a patient with advanced oral squamous cell carcinoma: A case report",

abstract = "Methadone, a synthetic opioid agonist, is used for pain that is refractory to other opioids. However, limited data on its ability to control pain in patients with oral cancer are available. In this study, we present a case of recurrent oral cancer, in which pain was poorly controlled with high-dose oxycodone but successfully controlled with methadone. A 36-year-old male patient was referred to our hospital for the treatment of recurrent oral cancer. His pain no longer responded to increased dosages of oxycodone, and thus oxycodone was switched to methadone. Ultimately, his pain was successfully controlled with methadone throughout his end-of-life stage.",

keywords = "Cancer pain, Methadone, Opioids, Oral squamous cell carcinoma, Palliative care",

author = "Katsuhisa Sekido and Kei Tomihara and Hideyo Horikawa and Hidetake Tachinami and Nozomu Murakami and Makoto Noguchi",

note = "Publisher Copyright: {\textcopyright} 2018 Japanese Stomatological Society",

year = "2018",

month = jul,

doi = "10.1016/S1348-8643(18)30004-1",

language = "英語",

volume = "15",

pages = "78--80",

journal = "Oral Science International",

issn = "1348-8643",

publisher = "The Japanese Stomatological Society",

number = "2",

}

TY - JOUR

T1 - Successful control of opioid-refractory cancer pain with methadone in a patient with advanced oral squamous cell carcinoma

T2 - A case report

AU - Sekido, Katsuhisa

AU - Tomihara, Kei

AU - Horikawa, Hideyo

AU - Tachinami, Hidetake

AU - Murakami, Nozomu

AU - Noguchi, Makoto

PY - 2018/7

Y1 - 2018/7

N2 - Methadone, a synthetic opioid agonist, is used for pain that is refractory to other opioids. However, limited data on its ability to control pain in patients with oral cancer are available. In this study, we present a case of recurrent oral cancer, in which pain was poorly controlled with high-dose oxycodone but successfully controlled with methadone. A 36-year-old male patient was referred to our hospital for the treatment of recurrent oral cancer. His pain no longer responded to increased dosages of oxycodone, and thus oxycodone was switched to methadone. Ultimately, his pain was successfully controlled with methadone throughout his end-of-life stage.

AB - Methadone, a synthetic opioid agonist, is used for pain that is refractory to other opioids. However, limited data on its ability to control pain in patients with oral cancer are available. In this study, we present a case of recurrent oral cancer, in which pain was poorly controlled with high-dose oxycodone but successfully controlled with methadone. A 36-year-old male patient was referred to our hospital for the treatment of recurrent oral cancer. His pain no longer responded to increased dosages of oxycodone, and thus oxycodone was switched to methadone. Ultimately, his pain was successfully controlled with methadone throughout his end-of-life stage.

KW - Cancer pain

KW - Methadone

KW - Opioids

KW - Oral squamous cell carcinoma

KW - Palliative care

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U2 - 10.1016/S1348-8643(18)30004-1

DO - 10.1016/S1348-8643(18)30004-1

M3 - 学術論文

AN - SCOPUS:85042876331

SN - 1348-8643

VL - 15

SP - 78

EP - 80

JO - Oral Science International

JF - Oral Science International

IS - 2

ER -

Successful control of opioid-refractory cancer pain with methadone in a patient with advanced oral squamous cell carcinoma: A case report

Abstract

Keywords

ASJC Scopus subject areas

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