Abstract
Four neutral polysaccharides (BRN-1, BRN-2, BRN-3 and BRN-4) were isolated from the hot water extract of the aerial part of Basella rubra L. They were found to consist of a large amount of d-galactose (81.0-92.4%) and small amounts of l-arabinose (5.4-7.8%), d-glucose (2.2-11.0%) and mannose (∼2.9%). Linkage analysis revealed that all these neutral polysaccharides might be arabinogalactan type I polysaccharides in different molecular weight and chain length. Among them, only BRN-3 showed antiviral activity against herpes simplex virus type 2 (HSV-2) with 50% inhibitory concentration of 55 μg/mL without showing the cytotoxicity up to 2300 μg/mL. Furthermore, the main antiviral target of BRN-3 was shown to be the inhibition of virus adsorption to host cells. This is the first report on the neutral polysaccharide with anti-HSV-2 activity obtained from B. rubra L.
| Original language | English |
|---|---|
| Pages (from-to) | 245-249 |
| Number of pages | 5 |
| Journal | International Journal of Biological Macromolecules |
| Volume | 50 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2012/01/01 |
Keywords
- Arabinogalactan
- Herpes simplex virus type 2
- Mode of antiviral action
ASJC Scopus subject areas
- Structural Biology
- Biochemistry
- Molecular Biology
- Economics and Econometrics
- General Energy