Structure of chloro(cyclopentadienone)-(cyclopentadienyl)ruthenium and its cytotoxic activity

Yoshimitsu Yamazaki; Midori Goto; Yu Ichi Kageyama; Takenori Tomohiro; Hiroaki Okuno

doi:10.1515/znb-1996-0222

Structure of chloro(cyclopentadienone)-(cyclopentadienyl)ruthenium and its cytotoxic activity

Yoshimitsu Yamazaki^*, Midori Goto, Yu Ichi Kageyama, Takenori Tomohiro, Hiroaki Okuno

^*Corresponding author for this work

Biorecognition Chemistry

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The structure of Ru(cpO)(cp)Cl complex (3), which was precipitated from aqueous solutions of Ru(cp)2Cl⁺PF₆^- (1), was determined by X-ray crystallographic analysis. The Ru-halogen bond distance was shorter and the dihedral angle between the rings was larger than the values reported for the corresponding Br analogue, Ru(cpO)(cp)Br (4). The complex 3 (IC₅₀ 109 μM) was more cytotoxic than 1 (IC₅₀ 163 μM) against mouse sarcoma S180 cells, but less toxic than 4 (IC₅₀ 72 μM).

Original language	English
Pages (from-to)	301-303
Number of pages	3
Journal	Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
Volume	51
Issue number	2
DOIs	https://doi.org/10.1515/znb-1996-0222
State	Published - 1996/02

Keywords

Cyclic voltammetry
Cytotoxicity
Ruthenium complex
X-ray

ASJC Scopus subject areas

General Chemistry

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10.1515/znb-1996-0222

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title = "Structure of chloro(cyclopentadienone)-(cyclopentadienyl)ruthenium and its cytotoxic activity",

abstract = "The structure of Ru(cpO)(cp)Cl complex (3), which was precipitated from aqueous solutions of Ru(cp)2Cl+PF6- (1), was determined by X-ray crystallographic analysis. The Ru-halogen bond distance was shorter and the dihedral angle between the rings was larger than the values reported for the corresponding Br analogue, Ru(cpO)(cp)Br (4). The complex 3 (IC50 109 μM) was more cytotoxic than 1 (IC50 163 μM) against mouse sarcoma S180 cells, but less toxic than 4 (IC50 72 μM).",

keywords = "Cyclic voltammetry, Cytotoxicity, Ruthenium complex, X-ray",

author = "Yoshimitsu Yamazaki and Midori Goto and Kageyama, {Yu Ichi} and Takenori Tomohiro and Hiroaki Okuno",

year = "1996",

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doi = "10.1515/znb-1996-0222",

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T1 - Structure of chloro(cyclopentadienone)-(cyclopentadienyl)ruthenium and its cytotoxic activity

AU - Yamazaki, Yoshimitsu

AU - Goto, Midori

AU - Kageyama, Yu Ichi

AU - Tomohiro, Takenori

AU - Okuno, Hiroaki

PY - 1996/2

Y1 - 1996/2

N2 - The structure of Ru(cpO)(cp)Cl complex (3), which was precipitated from aqueous solutions of Ru(cp)2Cl+PF6- (1), was determined by X-ray crystallographic analysis. The Ru-halogen bond distance was shorter and the dihedral angle between the rings was larger than the values reported for the corresponding Br analogue, Ru(cpO)(cp)Br (4). The complex 3 (IC50 109 μM) was more cytotoxic than 1 (IC50 163 μM) against mouse sarcoma S180 cells, but less toxic than 4 (IC50 72 μM).

AB - The structure of Ru(cpO)(cp)Cl complex (3), which was precipitated from aqueous solutions of Ru(cp)2Cl+PF6- (1), was determined by X-ray crystallographic analysis. The Ru-halogen bond distance was shorter and the dihedral angle between the rings was larger than the values reported for the corresponding Br analogue, Ru(cpO)(cp)Br (4). The complex 3 (IC50 109 μM) was more cytotoxic than 1 (IC50 163 μM) against mouse sarcoma S180 cells, but less toxic than 4 (IC50 72 μM).

KW - Cyclic voltammetry

KW - Cytotoxicity

KW - Ruthenium complex

KW - X-ray

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U2 - 10.1515/znb-1996-0222

DO - 10.1515/znb-1996-0222

M3 - 学術論文

AN - SCOPUS:0038971575

SN - 0932-0776

VL - 51

SP - 301

EP - 303

JO - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences

JF - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences

IS - 2

ER -

Structure of chloro(cyclopentadienone)-(cyclopentadienyl)ruthenium and its cytotoxic activity

Abstract

Keywords

ASJC Scopus subject areas

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