Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β- amyloid toxicity

T. Kihara; S. Shimohama; M. Urushitani; H. Sawada; J. Kimura; T. Kume; T. Maeda; A. Akaike

doi:10.1016/S0006-8993(98)00138-3

Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β- amyloid toxicity

T. Kihara, S. Shimohama^*, M. Urushitani, H. Sawada, J. Kimura, T. Kume, T. Maeda, A. Akaike

^*Corresponding author for this work

Applied Pharmacology

Research output: Contribution to journal › Article › peer-review

192 Scopus citations

Abstract

We examined the effects of nicotinic receptor agonists against beta amyloid (Aβ) cytotoxicity to rat cortical neurons. Administration of nicotine protected against Aβ-induced neuronal death. This neuroprotection was blocked by dihydro-beta-erythroidine, an α4β2 nicotinic receptor antagonist. Furthermore, incubation with cytisine, a selective α4β2 nicotinic receptor agonist, inhibited Aβ cytotoxicity. These results suggest that α4β2 nicotinic receptor activation plays an important role in neuroprotection against Aβ cytotoxicity.

Original language	English
Pages (from-to)	331-334
Number of pages	4
Journal	Brain Research
Volume	792
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(98)00138-3
State	Published - 1998/05/11

Keywords

Alzheimer's disease
Cortex
Nicotine
α4β2
β-amyloid

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(98)00138-3

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title = "Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β- amyloid toxicity",

abstract = "We examined the effects of nicotinic receptor agonists against beta amyloid (Aβ) cytotoxicity to rat cortical neurons. Administration of nicotine protected against Aβ-induced neuronal death. This neuroprotection was blocked by dihydro-beta-erythroidine, an α4β2 nicotinic receptor antagonist. Furthermore, incubation with cytisine, a selective α4β2 nicotinic receptor agonist, inhibited Aβ cytotoxicity. These results suggest that α4β2 nicotinic receptor activation plays an important role in neuroprotection against Aβ cytotoxicity.",

keywords = "Alzheimer's disease, Cortex, Nicotine, α4β2, β-amyloid",

author = "T. Kihara and S. Shimohama and M. Urushitani and H. Sawada and J. Kimura and T. Kume and T. Maeda and A. Akaike",

note = "Funding Information: This study was supported in part by Grants-in-Aid from the Ministry of Education, Science, Sports, and Culture of Japan, and grants from the Ministry of Welfare of Japan, the Smoking Research Foundation, the Mitsui Life Social Welfare Foundation, the Takeda Medical Research Foundation, and the Kato Memorial Trust for Nambyo Research.",

year = "1998",

month = may,

day = "11",

doi = "10.1016/S0006-8993(98)00138-3",

language = "英語",

volume = "792",

pages = "331--334",

journal = "Brain Research",

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T1 - Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β- amyloid toxicity

AU - Kihara, T.

AU - Shimohama, S.

AU - Urushitani, M.

AU - Sawada, H.

AU - Kimura, J.

AU - Kume, T.

AU - Maeda, T.

AU - Akaike, A.

N1 - Funding Information: This study was supported in part by Grants-in-Aid from the Ministry of Education, Science, Sports, and Culture of Japan, and grants from the Ministry of Welfare of Japan, the Smoking Research Foundation, the Mitsui Life Social Welfare Foundation, the Takeda Medical Research Foundation, and the Kato Memorial Trust for Nambyo Research.

PY - 1998/5/11

Y1 - 1998/5/11

N2 - We examined the effects of nicotinic receptor agonists against beta amyloid (Aβ) cytotoxicity to rat cortical neurons. Administration of nicotine protected against Aβ-induced neuronal death. This neuroprotection was blocked by dihydro-beta-erythroidine, an α4β2 nicotinic receptor antagonist. Furthermore, incubation with cytisine, a selective α4β2 nicotinic receptor agonist, inhibited Aβ cytotoxicity. These results suggest that α4β2 nicotinic receptor activation plays an important role in neuroprotection against Aβ cytotoxicity.

AB - We examined the effects of nicotinic receptor agonists against beta amyloid (Aβ) cytotoxicity to rat cortical neurons. Administration of nicotine protected against Aβ-induced neuronal death. This neuroprotection was blocked by dihydro-beta-erythroidine, an α4β2 nicotinic receptor antagonist. Furthermore, incubation with cytisine, a selective α4β2 nicotinic receptor agonist, inhibited Aβ cytotoxicity. These results suggest that α4β2 nicotinic receptor activation plays an important role in neuroprotection against Aβ cytotoxicity.

KW - Alzheimer's disease

KW - Cortex

KW - Nicotine

KW - α4β2

KW - β-amyloid

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U2 - 10.1016/S0006-8993(98)00138-3

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JO - Brain Research

JF - Brain Research

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ER -

Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β- amyloid toxicity

Abstract

Keywords

ASJC Scopus subject areas

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