Stereoselective synthesis of the KJ ring system of yessotoxin by Pd(II)-catalyzed cyclization

Hajime Yokoyama; Kazuki Nishida; Takashi Togawa; Masaki Yamagami; Masahiro Miyazawa; Yoshiro Hirai

doi:10.1016/j.tetlet.2016.08.049

Stereoselective synthesis of the KJ ring system of yessotoxin by Pd(II)-catalyzed cyclization

Hajime Yokoyama^*, Kazuki Nishida, Takashi Togawa, Masaki Yamagami, Masahiro Miyazawa, Yoshiro Hirai

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Yessotoxin was isolated from the digestive glands of the scallop, Patinopecten yessoensis, and would be of use as a promising therapeutic tool. We attained the stereoselective construction of KJ ring system of yessotoxin by the intramolecular cyclization of the trisubstituted allylic alcohol using Pd(II) catalyst.

Original language	English
Pages (from-to)	4379-4381
Number of pages	3
Journal	Tetrahedron Letters
Volume	57
Issue number	39
DOIs	https://doi.org/10.1016/j.tetlet.2016.08.049
State	Published - 2016

Keywords

Cyclization
Palladium(II) catalyst
Stereoselective
Synthesis
Yessotoxin

ASJC Scopus subject areas

Organic Chemistry
Drug Discovery

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10.1016/j.tetlet.2016.08.049

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title = "Stereoselective synthesis of the KJ ring system of yessotoxin by Pd(II)-catalyzed cyclization",

abstract = "Yessotoxin was isolated from the digestive glands of the scallop, Patinopecten yessoensis, and would be of use as a promising therapeutic tool. We attained the stereoselective construction of KJ ring system of yessotoxin by the intramolecular cyclization of the trisubstituted allylic alcohol using Pd(II) catalyst.",

keywords = "Cyclization, Palladium(II) catalyst, Stereoselective, Synthesis, Yessotoxin",

author = "Hajime Yokoyama and Kazuki Nishida and Takashi Togawa and Masaki Yamagami and Masahiro Miyazawa and Yoshiro Hirai",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

year = "2016",

doi = "10.1016/j.tetlet.2016.08.049",

language = "英語",

volume = "57",

pages = "4379--4381",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - Stereoselective synthesis of the KJ ring system of yessotoxin by Pd(II)-catalyzed cyclization

AU - Yokoyama, Hajime

AU - Nishida, Kazuki

AU - Togawa, Takashi

AU - Yamagami, Masaki

AU - Miyazawa, Masahiro

AU - Hirai, Yoshiro

PY - 2016

Y1 - 2016

N2 - Yessotoxin was isolated from the digestive glands of the scallop, Patinopecten yessoensis, and would be of use as a promising therapeutic tool. We attained the stereoselective construction of KJ ring system of yessotoxin by the intramolecular cyclization of the trisubstituted allylic alcohol using Pd(II) catalyst.

AB - Yessotoxin was isolated from the digestive glands of the scallop, Patinopecten yessoensis, and would be of use as a promising therapeutic tool. We attained the stereoselective construction of KJ ring system of yessotoxin by the intramolecular cyclization of the trisubstituted allylic alcohol using Pd(II) catalyst.

KW - Cyclization

KW - Palladium(II) catalyst

KW - Stereoselective

KW - Synthesis

KW - Yessotoxin

UR - http://www.scopus.com/inward/record.url?scp=84985946936&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2016.08.049

DO - 10.1016/j.tetlet.2016.08.049

M3 - 学術論文

AN - SCOPUS:84985946936

SN - 0040-4039

VL - 57

SP - 4379

EP - 4381

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 39

ER -

Stereoselective synthesis of the KJ ring system of yessotoxin by Pd(II)-catalyzed cyclization

Abstract

Keywords

ASJC Scopus subject areas

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