Stereoselective synthesis of the KJ ring system of yessotoxin by Pd(II)-catalyzed cyclization

Hajime Yokoyama*, Kazuki Nishida, Takashi Togawa, Masaki Yamagami, Masahiro Miyazawa, Yoshiro Hirai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Yessotoxin was isolated from the digestive glands of the scallop, Patinopecten yessoensis, and would be of use as a promising therapeutic tool. We attained the stereoselective construction of KJ ring system of yessotoxin by the intramolecular cyclization of the trisubstituted allylic alcohol using Pd(II) catalyst.

Original languageEnglish
Pages (from-to)4379-4381
Number of pages3
JournalTetrahedron Letters
Volume57
Issue number39
DOIs
StatePublished - 2016

Keywords

  • Cyclization
  • Palladium(II) catalyst
  • Stereoselective
  • Synthesis
  • Yessotoxin

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery

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