Splenic marginal zone lymphoma presenting as myelofibrosis associated with bone marrow involvement of lymphoma cells which secrete a large amount of TGF-β

T. Matsunaga; N. Takemoto; N. Miyajima; T. Okuda; H. Nagashima; T. Sato; T. Terui; H. Sasaki; N. Ohmi; Y. Hirayama; Y. Tamura; Y. Niitsu

doi:10.1007/s00277-003-0806-y

Splenic marginal zone lymphoma presenting as myelofibrosis associated with bone marrow involvement of lymphoma cells which secrete a large amount of TGF-β

T. Matsunaga^*, N. Takemoto, N. Miyajima, T. Okuda, H. Nagashima, T. Sato, T. Terui, H. Sasaki, N. Ohmi, Y. Hirayama, Y. Tamura, Y. Niitsu

^*Corresponding author for this work

Hematology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We report here on a patient with splenic marginal zone lymphoma presenting diffuse fibrosis of bone marrow and spleen. After splenectomy and chemotherapy, bone marrow biopsy demonstrated an improvement of fibrosis. Plasma concentration of transforming growth factor (TGF)-β was much higher in this patient than in those of age-matched non-Hodgkin's lymphoma patients (n=5) at diagnosis, decreasing after resolution of myelofibrosis. Immunostaining with the TGF-β antibody revealed that the lymphoma cells in bone marrow and spleen were positive for TGF-β. TGF-β secreted by tumor cells was thought to stimulate the growth of fibroblasts and synthesize collagen in bone marrow and splenic fibroblasts, and play an important role in the development of marrow and splenic fibrosis in this patient. This is the first report of a patient with splenic marginal zone lymphoma presenting as myelofibrosis associated with bone marrow involvement of lymphoma cells which secrete a large amount of TGF-β.

Original language	English
Pages (from-to)	322-325
Number of pages	4
Journal	Annals of Hematology
Volume	83
Issue number	5
DOIs	https://doi.org/10.1007/s00277-003-0806-y
State	Published - 2004/05

Keywords

Myelofibrosis
Splenic marginal zone lymphoma
TGF-β

ASJC Scopus subject areas

Hematology

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10.1007/s00277-003-0806-y

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Matsunaga, T., Takemoto, N., Miyajima, N., Okuda, T., Nagashima, H., Sato, T., Terui, T., Sasaki, H., Ohmi, N., Hirayama, Y., Tamura, Y., & Niitsu, Y. (2004). Splenic marginal zone lymphoma presenting as myelofibrosis associated with bone marrow involvement of lymphoma cells which secrete a large amount of TGF-β. Annals of Hematology, 83(5), 322-325. https://doi.org/10.1007/s00277-003-0806-y

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title = "Splenic marginal zone lymphoma presenting as myelofibrosis associated with bone marrow involvement of lymphoma cells which secrete a large amount of TGF-β",

abstract = "We report here on a patient with splenic marginal zone lymphoma presenting diffuse fibrosis of bone marrow and spleen. After splenectomy and chemotherapy, bone marrow biopsy demonstrated an improvement of fibrosis. Plasma concentration of transforming growth factor (TGF)-β was much higher in this patient than in those of age-matched non-Hodgkin's lymphoma patients (n=5) at diagnosis, decreasing after resolution of myelofibrosis. Immunostaining with the TGF-β antibody revealed that the lymphoma cells in bone marrow and spleen were positive for TGF-β. TGF-β secreted by tumor cells was thought to stimulate the growth of fibroblasts and synthesize collagen in bone marrow and splenic fibroblasts, and play an important role in the development of marrow and splenic fibrosis in this patient. This is the first report of a patient with splenic marginal zone lymphoma presenting as myelofibrosis associated with bone marrow involvement of lymphoma cells which secrete a large amount of TGF-β.",

keywords = "Myelofibrosis, Splenic marginal zone lymphoma, TGF-β",

author = "T. Matsunaga and N. Takemoto and N. Miyajima and T. Okuda and H. Nagashima and T. Sato and T. Terui and H. Sasaki and N. Ohmi and Y. Hirayama and Y. Tamura and Y. Niitsu",

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Matsunaga, T, Takemoto, N, Miyajima, N, Okuda, T, Nagashima, H, Sato, T, Terui, T, Sasaki, H, Ohmi, N, Hirayama, Y, Tamura, Y & Niitsu, Y 2004, 'Splenic marginal zone lymphoma presenting as myelofibrosis associated with bone marrow involvement of lymphoma cells which secrete a large amount of TGF-β', Annals of Hematology, vol. 83, no. 5, pp. 322-325. https://doi.org/10.1007/s00277-003-0806-y

TY - JOUR

T1 - Splenic marginal zone lymphoma presenting as myelofibrosis associated with bone marrow involvement of lymphoma cells which secrete a large amount of TGF-β

AU - Matsunaga, T.

AU - Takemoto, N.

AU - Miyajima, N.

AU - Okuda, T.

AU - Nagashima, H.

AU - Sato, T.

AU - Terui, T.

AU - Sasaki, H.

AU - Ohmi, N.

AU - Hirayama, Y.

AU - Tamura, Y.

AU - Niitsu, Y.

PY - 2004/5

Y1 - 2004/5

N2 - We report here on a patient with splenic marginal zone lymphoma presenting diffuse fibrosis of bone marrow and spleen. After splenectomy and chemotherapy, bone marrow biopsy demonstrated an improvement of fibrosis. Plasma concentration of transforming growth factor (TGF)-β was much higher in this patient than in those of age-matched non-Hodgkin's lymphoma patients (n=5) at diagnosis, decreasing after resolution of myelofibrosis. Immunostaining with the TGF-β antibody revealed that the lymphoma cells in bone marrow and spleen were positive for TGF-β. TGF-β secreted by tumor cells was thought to stimulate the growth of fibroblasts and synthesize collagen in bone marrow and splenic fibroblasts, and play an important role in the development of marrow and splenic fibrosis in this patient. This is the first report of a patient with splenic marginal zone lymphoma presenting as myelofibrosis associated with bone marrow involvement of lymphoma cells which secrete a large amount of TGF-β.

AB - We report here on a patient with splenic marginal zone lymphoma presenting diffuse fibrosis of bone marrow and spleen. After splenectomy and chemotherapy, bone marrow biopsy demonstrated an improvement of fibrosis. Plasma concentration of transforming growth factor (TGF)-β was much higher in this patient than in those of age-matched non-Hodgkin's lymphoma patients (n=5) at diagnosis, decreasing after resolution of myelofibrosis. Immunostaining with the TGF-β antibody revealed that the lymphoma cells in bone marrow and spleen were positive for TGF-β. TGF-β secreted by tumor cells was thought to stimulate the growth of fibroblasts and synthesize collagen in bone marrow and splenic fibroblasts, and play an important role in the development of marrow and splenic fibrosis in this patient. This is the first report of a patient with splenic marginal zone lymphoma presenting as myelofibrosis associated with bone marrow involvement of lymphoma cells which secrete a large amount of TGF-β.

KW - Myelofibrosis

KW - Splenic marginal zone lymphoma

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SN - 0939-5555

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SP - 322

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JO - Annals of Hematology

JF - Annals of Hematology

IS - 5

ER -

Splenic marginal zone lymphoma presenting as myelofibrosis associated with bone marrow involvement of lymphoma cells which secrete a large amount of TGF-β

Abstract

Keywords

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