Size-selective recognition of gold nanoparticles by a molecular chaperone

Masafumi Sakono*, Tamotsu Zako, Srdja Drakulic, José María Valpuesta, Masafumi Yohda, Mizuo Maeda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Molecular chaperone prefoldin (PFD) assists protein folding by inhibition of protein aggregation in the cell. In this study, we investigated an interaction between gold nanoparticles (Au NPs) and the molecular chaperone PFD. We demonstrated that addition of PFD inhibits salt-induced aggregation of Au NPs. Interestingly, the interaction between PFD and Au NPs was observed to be Au-size dependent. As PFD has no thiol groups in the molecule, hydrophobic interaction is considered to be the primary interaction. This is the first demonstration of size-specific stabilization of Au NPs with non-covalent bonding.

Original languageEnglish
Pages (from-to)108-112
Number of pages5
JournalChemical Physics Letters
Volume501
Issue number1-3
DOIs
StatePublished - 2010/12/06

ASJC Scopus subject areas

  • General Physics and Astronomy
  • Physical and Theoretical Chemistry

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