TY - JOUR
T1 - Size-selective recognition of gold nanoparticles by a molecular chaperone
AU - Sakono, Masafumi
AU - Zako, Tamotsu
AU - Drakulic, Srdja
AU - Valpuesta, José María
AU - Yohda, Masafumi
AU - Maeda, Mizuo
N1 - Funding Information:
This work was supported by the Japan Science Technology Agency (PRESTO program) . This work was also supported by grant S2009MAT-1507 from the Madrid Regional Government (to JMV). SD is a recipient of ‘La Caixa’ foundation fellowship.
PY - 2010/12/6
Y1 - 2010/12/6
N2 - Molecular chaperone prefoldin (PFD) assists protein folding by inhibition of protein aggregation in the cell. In this study, we investigated an interaction between gold nanoparticles (Au NPs) and the molecular chaperone PFD. We demonstrated that addition of PFD inhibits salt-induced aggregation of Au NPs. Interestingly, the interaction between PFD and Au NPs was observed to be Au-size dependent. As PFD has no thiol groups in the molecule, hydrophobic interaction is considered to be the primary interaction. This is the first demonstration of size-specific stabilization of Au NPs with non-covalent bonding.
AB - Molecular chaperone prefoldin (PFD) assists protein folding by inhibition of protein aggregation in the cell. In this study, we investigated an interaction between gold nanoparticles (Au NPs) and the molecular chaperone PFD. We demonstrated that addition of PFD inhibits salt-induced aggregation of Au NPs. Interestingly, the interaction between PFD and Au NPs was observed to be Au-size dependent. As PFD has no thiol groups in the molecule, hydrophobic interaction is considered to be the primary interaction. This is the first demonstration of size-specific stabilization of Au NPs with non-covalent bonding.
UR - http://www.scopus.com/inward/record.url?scp=78649636203&partnerID=8YFLogxK
U2 - 10.1016/j.cplett.2010.10.035
DO - 10.1016/j.cplett.2010.10.035
M3 - 学術論文
AN - SCOPUS:78649636203
SN - 0009-2614
VL - 501
SP - 108
EP - 112
JO - Chemical Physics Letters
JF - Chemical Physics Letters
IS - 1-3
ER -