Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases

Introduction: The purpose of this study was to investigate the relation between preoperative cachexia index (CXI) and long-term outcomes in patients with colorectal liver metastases (CRLM) after hepatic resection. Method: In all,118 patients who underwent hepatic resection for CRLM were analyzed retrospectively. The relationship between CXI and the long-term outcomes in patients after hepatic resection was investigated. CXI was calculated based on preoperative skeletal muscle index, serum albumin level, and neutrophil–lymphocyte ratio. Results: The multivariate analysis showed that extrahepatic lesion (hazard ratio [HR] 2.86, 95% confidence interval [CI] 1.48–5.53, P <.01) and high CXI (HR 0.44, 95% CI 0.20–0.98, P =.04) were independent and significant predictors of disease-free survival. Moreover, extrahepatic lesion (HR 2.32, 95% CI 1.03–5.22, P =.04), high CXI (HR 0.17, 95% CI 0.05–0.57, P <.01), and curability R 1 or 2 (HR 3.29, 95% CI 1.23–8.78, P =.02) were independent and significant predictors of overall survival. Conclusion: CXI is a useful prognostic factor for disease-free survival and overall survival after hepatic resection in CRLM patients.