Selective Synthesis of Novel Anticancer Platinum Pyrimidine Greens by Hydrogen Peroxide Oxidation

Takehiko Shimura; Takenori Tomohiro; Hiroshi Moriyama; Toshimasa Uemura; Yohmei Okuno; Tarja Laitalainen

doi:10.1248/cpb.36.448

Selective Synthesis of Novel Anticancer Platinum Pyrimidine Greens by Hydrogen Peroxide Oxidation

Takehiko Shimura, Takenori Tomohiro, Hiroshi Moriyama, Toshimasa Uemura, Yohmei Okuno^*, Tarja Laitalainen

^*Corresponding author for this work

Biorecognition Chemistry

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Platinum greens can be synthesized effectively and selectively from aquated cis-diiododiammineplatinum(II) and pyrimidine derivatives with hydrogen peroxide under argon. By adjusting reaction temperature, time and the amount of oxidizing agent, various sizes of the molecule have been obtained. This method can be used with the different substrates and counter anions of the complexes.

Original language	English
Pages (from-to)	448-451
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	36
Issue number	1
DOIs	https://doi.org/10.1248/cpb.36.448
State	Published - 1988

Keywords

antitumor activity
hydrogen peroxide oxidation
platinum pyrimidine green
selective green formation
selective synthesis

ASJC Scopus subject areas

General Chemistry
Drug Discovery

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10.1248/cpb.36.448

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abstract = "Platinum greens can be synthesized effectively and selectively from aquated cis-diiododiammineplatinum(II) and pyrimidine derivatives with hydrogen peroxide under argon. By adjusting reaction temperature, time and the amount of oxidizing agent, various sizes of the molecule have been obtained. This method can be used with the different substrates and counter anions of the complexes.",

keywords = "antitumor activity, hydrogen peroxide oxidation, platinum pyrimidine green, selective green formation, selective synthesis",

author = "Takehiko Shimura and Takenori Tomohiro and Hiroshi Moriyama and Toshimasa Uemura and Yohmei Okuno and Tarja Laitalainen",

year = "1988",

doi = "10.1248/cpb.36.448",

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T1 - Selective Synthesis of Novel Anticancer Platinum Pyrimidine Greens by Hydrogen Peroxide Oxidation

AU - Shimura, Takehiko

AU - Tomohiro, Takenori

AU - Moriyama, Hiroshi

AU - Uemura, Toshimasa

AU - Okuno, Yohmei

AU - Laitalainen, Tarja

PY - 1988

Y1 - 1988

N2 - Platinum greens can be synthesized effectively and selectively from aquated cis-diiododiammineplatinum(II) and pyrimidine derivatives with hydrogen peroxide under argon. By adjusting reaction temperature, time and the amount of oxidizing agent, various sizes of the molecule have been obtained. This method can be used with the different substrates and counter anions of the complexes.

AB - Platinum greens can be synthesized effectively and selectively from aquated cis-diiododiammineplatinum(II) and pyrimidine derivatives with hydrogen peroxide under argon. By adjusting reaction temperature, time and the amount of oxidizing agent, various sizes of the molecule have been obtained. This method can be used with the different substrates and counter anions of the complexes.

KW - antitumor activity

KW - hydrogen peroxide oxidation

KW - platinum pyrimidine green

KW - selective green formation

KW - selective synthesis

UR - http://www.scopus.com/inward/record.url?scp=0023854138&partnerID=8YFLogxK

U2 - 10.1248/cpb.36.448

DO - 10.1248/cpb.36.448

M3 - 学術論文

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AN - SCOPUS:0023854138

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EP - 451

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 1

ER -

Selective Synthesis of Novel Anticancer Platinum Pyrimidine Greens by Hydrogen Peroxide Oxidation

Abstract

Keywords

ASJC Scopus subject areas

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