Abstract
The mechanism that regulates the growth of ovarian clear cell adenocarcinoma (CCA) are not well understood. We investigated the role of several growth factors that bind to membrane tyrosine kinase receptors and added them to the ovarian CCA cell lines KK, RMG-1, and HAC-II to evaluate their effect on growth and cellular invasion. Epidermal growth factor and transforming growth factor-α significantly stimulated the growth and invasion of CCA cell lines in vitro. ZD1839, an epidermal growth factor receptor-tyrosine kinase inhibitor, decreased the growth and invasion of CCA cell lines in vitro and in vivo inhibited the growth of xenografts of the CCA cell line RMG-1. Severe combined immunodeficient mice bearing RMG-1 xenografts treated with ZD1839 survived for longer than the untreated control group. From these findings, we conclude that ZD1839 may offer a new and effective treatment for ovarian CCA.
| Original language | English |
|---|---|
| Pages (from-to) | 2448-2454 |
| Number of pages | 7 |
| Journal | Clinical Cancer Research |
| Volume | 8 |
| Issue number | 7 |
| State | Published - 2002 |
ASJC Scopus subject areas
- Oncology
- Cancer Research
